Ignite Creation Date:
2024-05-06 @ 7:41 PM
Last Modification Date:
2024-10-26 @ 3:12 PM
Study NCT ID:
NCT06102629
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-10-26
First Post:
2023-10-21
Brief Title:
Ovary Syndrome for Efficient Diagnosis and Targeted Therapy
Sponsor:
Asian Institute of Gastroenterology India
Organization:
Asian Institute of Gastroenterology India
Study Overview
Official Title:
Understanding the Epigenetic Mechanisms in the Pathophysiology of Polycystic Ovary Syndrome for Efficient Diagnosis and Targeted Therapy
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PCOS-01
Brief Summary:
OBJECTIVES
1 Analysis of DNA methyl transferases DNMT1 DNMT3A and DNMT3B and Histone deacetylases HDAC 123 and SIRTs polymorphisms Somatic and germ line variations
2 Analysis of differential mRNA and protein expression of epigenetic markers in ovarian tissues obtained from PCOS patients
3 miRNA regulated epigenetic mechanisms in PCOS
4 Epigenetic regulation of endocrine genes in PCOS
DESIGN A Case Control studySample size200
1 Analysis of DNA methyl transferases DNMT1 DNMT3A and DNMT3B and Histone deacetylases HDAC 123 and SIRTs polymorphisms Somatic and germ line variations
2 Analysis of differential mRNA and protein expression of epigenetic markers in ovarian tissues obtained from PCOS patients
3 miRNA regulated epigenetic mechanisms in PCOS
4 Epigenetic regulation of endocrine genes in PCOS
DESIGN A Case Control studySample size200
Detailed Description:
1 We will take both blood and ovarian tissue samples used to diagnosis
2 We will take approximately 3 ml of blood which will be used from the blood sample collected for routine preoperative tests surgical profile before their planned surgery or for disease evaluation
3 Small tissue samples from ovary will be taken from the tissue which is surgically excised as a part of treatment
2 We will take approximately 3 ml of blood which will be used from the blood sample collected for routine preoperative tests surgical profile before their planned surgery or for disease evaluation
3 Small tissue samples from ovary will be taken from the tissue which is surgically excised as a part of treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None