Ignite Creation Date:
2024-05-06 @ 7:41 PM
Last Modification Date:
2024-10-26 @ 3:11 PM
Study NCT ID:
NCT06094569
Status:
RECRUITING
Last Update Posted:
2023-10-23
First Post:
2023-10-16
Brief Title:
Medical Imaging Screening for Posterior-circulation Ischemic Stroke
Sponsor:
Tianjin Huanhu Hospital
Organization:
Tianjin Huanhu Hospital
Study Overview
Official Title:
Medical Imaging Screening for Posterior-circulation Ischemic Strokea MulticentreImaging-basedProspective Cohort Study
Status:
RECRUITING
Status Verified Date:
2023-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients with ischemic stroke in the posterior circulation continue to have high rates of mortality and disability even with aggressive treatment We wanted to evaluate preoperative imaging to screen patients with a good prognosis from mechanical embolization We assess the degree of ischemia by defining the pons-midbrain-medulla index PMMI and correlate the preoperative PMMI with the clinical prognosis of postoperative patients to verify the validity of PMMI in predicting the clinical prognosis of patients with embolization
Detailed Description:
The ENDOSTROKE registry Endovascular Stroke T reatment Registry the use of MRI before EVT was associated with significantly better clinical outcomes as compared to CT
The purpose of the study will sift patients with posterior circulation ischemia stroke who will get better outcome by Mechanical Thrombectomy by neuroimagingSpecifically the following assumption will be evaluated the modified pons-midbrain index in magnetic resonance imaging can predict the clinical outcome of patients with basilar artery thrombosis 90 days after surgery and can guide whether patients will undergo mechanical thrombectomy later
Pons-midbrain-medulla index PMMI We divide pons-midbrain-medulla into the left and right sides by the median line of the brainstemso we will evaluate ischemia of these six layers which are endowed different score according to the degree of ischemia Instead of the previous pons-midbrain index PMI we select the image layer that shows the largest infarct size among the six partsThenwe add up six scores that is patients PMMI Scoring criteria At the layer of displaying the maximum infarct size 2 points are scored if the infarct size exceeds 50 of the total area 1 point is scored if the infarct size is less than 50 of the total area and 0 points are scored if there is no infarctFinally PMMI values range from 0 to 12 points
The investigators conduct a multicenter prospective cohort studyPreoperative images of patients are evaluated by different groups of imaging physicians to describe the association between preoperative PMMI and clinical prognosis in patients with posterior circulation stroke and to verify its validity
The purpose of the study will sift patients with posterior circulation ischemia stroke who will get better outcome by Mechanical Thrombectomy by neuroimagingSpecifically the following assumption will be evaluated the modified pons-midbrain index in magnetic resonance imaging can predict the clinical outcome of patients with basilar artery thrombosis 90 days after surgery and can guide whether patients will undergo mechanical thrombectomy later
Pons-midbrain-medulla index PMMI We divide pons-midbrain-medulla into the left and right sides by the median line of the brainstemso we will evaluate ischemia of these six layers which are endowed different score according to the degree of ischemia Instead of the previous pons-midbrain index PMI we select the image layer that shows the largest infarct size among the six partsThenwe add up six scores that is patients PMMI Scoring criteria At the layer of displaying the maximum infarct size 2 points are scored if the infarct size exceeds 50 of the total area 1 point is scored if the infarct size is less than 50 of the total area and 0 points are scored if there is no infarctFinally PMMI values range from 0 to 12 points
The investigators conduct a multicenter prospective cohort studyPreoperative images of patients are evaluated by different groups of imaging physicians to describe the association between preoperative PMMI and clinical prognosis in patients with posterior circulation stroke and to verify its validity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None