Ignite Creation Date:
2024-05-06 @ 7:41 PM
Last Modification Date:
2024-10-26 @ 3:11 PM
Study NCT ID:
NCT06091592
Status:
COMPLETED
Last Update Posted:
2023-10-19
First Post:
2023-10-14
Brief Title:
The dıagnostıc Value of Serum autotaxın Level ın Colorectal Cancer
Sponsor:
Diskapi Yildirim Beyazit Education and Research Hospital
Organization:
Diskapi Yildirim Beyazit Education and Research Hospital
Study Overview
Official Title:
Serum autotaxın Level ın Colorectal Cancer
Status:
COMPLETED
Status Verified Date:
2023-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Colorectal cancer is one of the most common causes of cancer-related death Early diagnosis is extremely important in terms of treatment and mortality In this study we investigated the diagnostic value of serum autotaxin levels in colorectal cancer
Detailed Description:
Colorectal cancer CRC is the third most common type of cancer worldwide Among the causes of death due to cancer it is the second most common among both genders with a rate of 92 after lung cancer Early detection of the disease is important for survival National screening programs attempt to detect this disease at an early stage
Autotaxin ATX molecule is a member of the nucleotide pyrophosphatasephosphodiesterase enzyme family ENNP It is secreted at 125 kDa has lysophospholipase D activity in the lysophosphatidic acid LPA pathway and is located at the 24th locus of the long arm of the 8th chromosome This is also called ENPP2 It was discovered to be an autocrine motility-stimulating factor released by human melanoma A-2058 cells Lysophosphatidic acid LPA is a lipid signalling molecule located in the cell membrane LPA functions as an autocrineparacrine messenger through at least six G protein-coupled receptors GPCR known as LPA 1-6 It plays physiologically important roles in various cellular processes including wound healing differentiation cell proliferation and migration The role of ATX in the bioactivity of LPA is correlated with the lysophosphatidyl-D lysoPLD activity of ATX ATX molecule With this enzyme activity it plays a fundamental role in the conversion of lysophosphatidylcholine to lysophosphatidic acid Many studies have demonstrated the biological effects of the autotaxin-lysophosphatidic acid ATX-LPA signalling pathway in cancer In vitro and in vivo studies have shown that increased ATX-LPA signalling contributes to cancer initiation and progression Current evidence supports the role of the ATX-LPA signalling pathway in the proliferation invasion adhesion and angiogenesis of cells and is effective in cancer development and metastasis Increased ATX expression has been reported in various cancers such as glioblastoma hepatocellular and thyroid carcinomas breast pancreatic colon and hematological cancers
The ATX molecule has the feature of being a molecule that will be effective in the future not only in the diagnosis of cancer but also in the treatment process and to be studied extensively in this study we aimed to examine the diagnostic and biological behaviour relationship between serum ATX levels and colorectal cancer and to determine the cut-off value for serum ATX levels in colorectal cancer
Serum ATX levels were compared between the patient and control groups ATX levels were analysed in subgroups formed according to the demographic clinical pathological and laboratory characteristics of the patient group
Autotaxin ATX molecule is a member of the nucleotide pyrophosphatasephosphodiesterase enzyme family ENNP It is secreted at 125 kDa has lysophospholipase D activity in the lysophosphatidic acid LPA pathway and is located at the 24th locus of the long arm of the 8th chromosome This is also called ENPP2 It was discovered to be an autocrine motility-stimulating factor released by human melanoma A-2058 cells Lysophosphatidic acid LPA is a lipid signalling molecule located in the cell membrane LPA functions as an autocrineparacrine messenger through at least six G protein-coupled receptors GPCR known as LPA 1-6 It plays physiologically important roles in various cellular processes including wound healing differentiation cell proliferation and migration The role of ATX in the bioactivity of LPA is correlated with the lysophosphatidyl-D lysoPLD activity of ATX ATX molecule With this enzyme activity it plays a fundamental role in the conversion of lysophosphatidylcholine to lysophosphatidic acid Many studies have demonstrated the biological effects of the autotaxin-lysophosphatidic acid ATX-LPA signalling pathway in cancer In vitro and in vivo studies have shown that increased ATX-LPA signalling contributes to cancer initiation and progression Current evidence supports the role of the ATX-LPA signalling pathway in the proliferation invasion adhesion and angiogenesis of cells and is effective in cancer development and metastasis Increased ATX expression has been reported in various cancers such as glioblastoma hepatocellular and thyroid carcinomas breast pancreatic colon and hematological cancers
The ATX molecule has the feature of being a molecule that will be effective in the future not only in the diagnosis of cancer but also in the treatment process and to be studied extensively in this study we aimed to examine the diagnostic and biological behaviour relationship between serum ATX levels and colorectal cancer and to determine the cut-off value for serum ATX levels in colorectal cancer
Serum ATX levels were compared between the patient and control groups ATX levels were analysed in subgroups formed according to the demographic clinical pathological and laboratory characteristics of the patient group
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None