Ignite Creation Date:
2024-05-06 @ 7:41 PM
Last Modification Date:
2024-10-26 @ 3:11 PM
Study NCT ID:
NCT06099340
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-10-25
First Post:
2023-10-09
Brief Title:
Effects of an Eccentric Muscle Strengthening Protocol on Force Moment Muscle Activation and Plantar Flexor Structure of Patients With Central Nervous System Injuries
Sponsor:
Nantes University Hospital
Organization:
Nantes University Hospital
Study Overview
Official Title:
Effects of an Eccentric Muscle Strengthening Protocol on Force Moment Muscle Activation and Plantar Flexor Structure in Patients With Central Nervous System Injuries A Randomized Controlled Trial in Post-stroke Patients and a Pilot Study in Spinal Cord Injured Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RenfExc
Brief Summary:
Neurological disorders such as Cerebral Vascular Accident CVA or Spinal Cord Injury SCI are among the most costly health problems to society in industrialized countries For those affected they generate severe restrictions in mobility significantly altering their quality of life
Deterioration in motor function after stroke or BM is closely linked to the level of force produced at joint level This is influenced by adaptations neurological and tissue inherent to the pathophysiology of the injury and characterized by the presence of a spastic paresis syndrome
A great deal of effort is devoted to motor neurorehabilitation particularly physiotherapy in the days and weeks following neurological injury This so-called sub-acute rehabilitation phase is designed to have a positive impact on the patients motor recovery to prevent the development of spastic paresis and to prevent future severe limitations in the long term
Disorders observed in the chronic phase partial recovery of strength severe orthopedic deformities demonstrate the limits of current therapies In view of the results obtained in healthy subjects eccentric training now seems to be one of the most promising physiotherapy methods for recovering muscle strength and countering neurological disorders
However its use in the sub-acute rehabilitation phase has never been evaluated in post-stroke or post-BM patients either in terms of its effects on the strength developed in the strengthened muscles or more locally on the neurological and tissue disorders found in these patients in the context of spastic paresis
The aim of this project is to evaluate the effects of an eccentric muscle-strengthening exercise protocol on neurological patients in the sub-acute phase of their neurological impairment The protocol will be applied to the ankle joint given its importance for walking and the significant deficits found at this level in neurological populationsWe hypothesize that the strengthening protocol will improve muscle strength at the ankle and generate beneficial adaptations to combat the spastic paresis syndrome improved muscle activation increased muscle length muscle volume etc
Deterioration in motor function after stroke or BM is closely linked to the level of force produced at joint level This is influenced by adaptations neurological and tissue inherent to the pathophysiology of the injury and characterized by the presence of a spastic paresis syndrome
A great deal of effort is devoted to motor neurorehabilitation particularly physiotherapy in the days and weeks following neurological injury This so-called sub-acute rehabilitation phase is designed to have a positive impact on the patients motor recovery to prevent the development of spastic paresis and to prevent future severe limitations in the long term
Disorders observed in the chronic phase partial recovery of strength severe orthopedic deformities demonstrate the limits of current therapies In view of the results obtained in healthy subjects eccentric training now seems to be one of the most promising physiotherapy methods for recovering muscle strength and countering neurological disorders
However its use in the sub-acute rehabilitation phase has never been evaluated in post-stroke or post-BM patients either in terms of its effects on the strength developed in the strengthened muscles or more locally on the neurological and tissue disorders found in these patients in the context of spastic paresis
The aim of this project is to evaluate the effects of an eccentric muscle-strengthening exercise protocol on neurological patients in the sub-acute phase of their neurological impairment The protocol will be applied to the ankle joint given its importance for walking and the significant deficits found at this level in neurological populationsWe hypothesize that the strengthening protocol will improve muscle strength at the ankle and generate beneficial adaptations to combat the spastic paresis syndrome improved muscle activation increased muscle length muscle volume etc
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None