Ignite Creation Date:
2024-05-06 @ 7:41 PM
Last Modification Date:
2024-10-26 @ 3:11 PM
Study NCT ID:
NCT06098794
Status:
COMPLETED
Last Update Posted:
2023-10-25
First Post:
2023-10-06
Brief Title:
Effect of Sodium Bicarbonate on Exercise Performance
Sponsor:
Faculdade de Motricidade Humana
Organization:
Faculdade de Motricidade Humana
Study Overview
Official Title:
The Effects of Sodium Bicarbonate Supplementation on Intense Exercise Performance
Status:
COMPLETED
Status Verified Date:
2023-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This was a randomized double-blind placebo controlled crossover trial The study aimed to assess the effect of sodium bicarbonate on the ability to perform a repeated sprint task by female football players The researches hypothesis was that sodium bicarbonate increases the ability to remove lactic acid from muscle cells reducing its intracellular accumulation and increasing energetic efficiency resulting in the increase of peak power output mean power output or total work or in the decrease of the sprint decrement in each set of the repeated sprints task
Detailed Description:
Experimental design The study consisted of a randomized double-blind controlled crossover trial where 11 female football players performed in a randomized order two repeated sprints tasks in a cycle ergometer after having ingested either sodium bicarbonate SB or placebo PL Body composition of the athletes was characterized by bioelectrical impedance analysis with a single frequency 50 kHz device BIA 101 Anniversary Akern Florence Italy before the exercise sessions Data collection was separated by a period of at least one week within a period of time not exceeding one month and performed at the same time of the day for each participant Data regarding performance blood lactate accumulation pulmonary gas exchange heart rate HR muscle oxygenation and neuromuscular fatigue were collected during these two sessions
Supplementation protocol The participants ingested capsules containing 03 gkg of body weight of SB or cellulose as PL divided into two doses The first intake 02 gkg occurred 2 h before the beginning of the protocol and the second 01 gkg occurred 1 h later Possible gastrointestinal symptoms associated with supplement ingestion were controlled with a questionnaire based on the questionnaire applied by Miller et al 2016
Repeated sprints protocol The RSA protocol was performed in a cycle ergometer Monark Ergomedic 894 E Monark Exercise AB Vansbro Sweden and was composed of 3 sets of 6 sprints with 6 s duration with a workload of 4 of the body mass Repetitions were separated by 24 s of active recovery and participants were conceded 5 min of passive recovery to rest between sets The protocol was preceded by a 5-min warm-up in which athletes pedalled at a speed of 60 to 70 rpm
Performance Measurements Performance was evaluated by monitoring peak power output mean power output total work and the sprint decrement in each set of the two repeated sprints task
Blood lactate accumulation Lactate concentration was assessed Lactate Pro 2 KDK Corporation Kyoto Japan in capillary blood from the ear lobe before the beginning of each protocol 1 min after the end of each set and at min 1 and every 2 min after the tasks were completed until the value started to decrease At the end of the tasks the maximal values achieved were considered for analysis
Pulmonary gas exchange and heart rate Oxygen uptake carbon dioxide production and ventilation VO2 VCO2 VE respectively were measured breath-by-breath during the protocol using a gas analyser MetaMax 3B Cortex Biophysik Leipzig Germany Heart rate was continuously evaluated using an HR monitor H7 Polar Electro Oy Kempele Finland The integral of VO2 L and VCO2 L and the maximum 6-s moving average of relative VO2 mLkgmin VE Lmin and HR bpm were calculated for each set
Muscle oxygenation Throughout the protocol oxygenated O2Hb and deoxygenated haemoglobin HHb were continuously monitored with a near-infrared spectroscopy device Niro-200NX Hamamatsu Phototonics Hamamatsu Japan according with the manufacturer specifications The integrals of O2Hb and HHb were calculated for each set of the protocol
Neuromuscular fatigue assessment Athletes executed a countermovement jump CMJ in a contact mat Chronojump BoscoSystem Software Version 220 Barcelona Spain before and after the exercise protocol accessing values of jump height JH Three jumps were performed separated by 30 s of rest and the best jump was considered for analysis
Data analysis Power and sample calculations G-Power Version 3192 Düsseldorf Germany were based on an effect size of 088 McNaughton et al 1997 for total work performed in the sprints a power of 085 and a significance of 005 After the recruitment process 12 athletes volunteered to participate in the study One volunteer withdrew due to injury leading to a sample size of 11 athletes Statistical analysis was performed using the Statistical Package for the Social Sciences IBM Corp SPSS v270 Armonk NY USA and R software v420 Open-Source Code General Public License Normal distribution and sphericity were tested using Shapiro-Wilks and Mauchlys tests respectively For variables with normal distribution data was analysed using a two-way analysis of variance ANOVA Whenever a statistical significance was observed in the two-way ANOVA post-hoc paired comparisons were performed with the Bonferroni correction Statistical significance was set at p 005 If normal distribution was not verified the nparLD module of the R software was used to perform a non-parametric two-way ANOVA-type test and if any significant result was observed a Friedman test and the post-hoc paired comparisons with the Bonferroni correction as well as a Wilcoxon test were performed Statistical significance was adjusted according with the number of tests performed for each factor
Supplementation protocol The participants ingested capsules containing 03 gkg of body weight of SB or cellulose as PL divided into two doses The first intake 02 gkg occurred 2 h before the beginning of the protocol and the second 01 gkg occurred 1 h later Possible gastrointestinal symptoms associated with supplement ingestion were controlled with a questionnaire based on the questionnaire applied by Miller et al 2016
Repeated sprints protocol The RSA protocol was performed in a cycle ergometer Monark Ergomedic 894 E Monark Exercise AB Vansbro Sweden and was composed of 3 sets of 6 sprints with 6 s duration with a workload of 4 of the body mass Repetitions were separated by 24 s of active recovery and participants were conceded 5 min of passive recovery to rest between sets The protocol was preceded by a 5-min warm-up in which athletes pedalled at a speed of 60 to 70 rpm
Performance Measurements Performance was evaluated by monitoring peak power output mean power output total work and the sprint decrement in each set of the two repeated sprints task
Blood lactate accumulation Lactate concentration was assessed Lactate Pro 2 KDK Corporation Kyoto Japan in capillary blood from the ear lobe before the beginning of each protocol 1 min after the end of each set and at min 1 and every 2 min after the tasks were completed until the value started to decrease At the end of the tasks the maximal values achieved were considered for analysis
Pulmonary gas exchange and heart rate Oxygen uptake carbon dioxide production and ventilation VO2 VCO2 VE respectively were measured breath-by-breath during the protocol using a gas analyser MetaMax 3B Cortex Biophysik Leipzig Germany Heart rate was continuously evaluated using an HR monitor H7 Polar Electro Oy Kempele Finland The integral of VO2 L and VCO2 L and the maximum 6-s moving average of relative VO2 mLkgmin VE Lmin and HR bpm were calculated for each set
Muscle oxygenation Throughout the protocol oxygenated O2Hb and deoxygenated haemoglobin HHb were continuously monitored with a near-infrared spectroscopy device Niro-200NX Hamamatsu Phototonics Hamamatsu Japan according with the manufacturer specifications The integrals of O2Hb and HHb were calculated for each set of the protocol
Neuromuscular fatigue assessment Athletes executed a countermovement jump CMJ in a contact mat Chronojump BoscoSystem Software Version 220 Barcelona Spain before and after the exercise protocol accessing values of jump height JH Three jumps were performed separated by 30 s of rest and the best jump was considered for analysis
Data analysis Power and sample calculations G-Power Version 3192 Düsseldorf Germany were based on an effect size of 088 McNaughton et al 1997 for total work performed in the sprints a power of 085 and a significance of 005 After the recruitment process 12 athletes volunteered to participate in the study One volunteer withdrew due to injury leading to a sample size of 11 athletes Statistical analysis was performed using the Statistical Package for the Social Sciences IBM Corp SPSS v270 Armonk NY USA and R software v420 Open-Source Code General Public License Normal distribution and sphericity were tested using Shapiro-Wilks and Mauchlys tests respectively For variables with normal distribution data was analysed using a two-way analysis of variance ANOVA Whenever a statistical significance was observed in the two-way ANOVA post-hoc paired comparisons were performed with the Bonferroni correction Statistical significance was set at p 005 If normal distribution was not verified the nparLD module of the R software was used to perform a non-parametric two-way ANOVA-type test and if any significant result was observed a Friedman test and the post-hoc paired comparisons with the Bonferroni correction as well as a Wilcoxon test were performed Statistical significance was adjusted according with the number of tests performed for each factor
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None