Ignite Creation Date:
2024-05-06 @ 7:40 PM
Last Modification Date:
2024-10-26 @ 3:11 PM
Study NCT ID:
NCT06094998
Status:
COMPLETED
Last Update Posted:
2024-03-07
First Post:
2023-10-17
Brief Title:
Health Status of Children Born After Assisted Reproductive Technologies
Sponsor:
Kazakhstans Medical University KSPH
Organization:
Kazakhstans Medical University KSPH
Study Overview
Official Title:
Health Status of Children Born After Assisted Reproductive Technologies With the Development of Prediction Model and Principles of Child Management
Status:
COMPLETED
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this observational study is to study the features of psychophysical development and the morbidity patterns of children born after assisted pregnancy and to identify the connection with the health status of mothers followed by the development of a prediction model and general principles of management of children born after ART The main questions it aims to answer are the influence of premorbid background of mothers on childrens physical development disease occurrence and morbidity patterns of children born as after ART
To identify the indicators of cellular and humoral immunity in children born after different oocyte fertilization methods in IVF programs classical IVF or ICSI
To study the long-term effects of ART on the endocrine status of children
It will be studied hemogram examination immunity indicators cellular components CD3 CD4 CD8 CD16 CD20 CD25 CD95 CD3 HLA DR CD HLA-DR humoral components - IgM IgA IgE IgG and laboratory investigations in endocrine system TSH free T3 and T4 levels insulin insulin-like growth factor-1 IGF-1 somatotropic hormone STH glucose potassium sodium in 120 children born after ART Researchers will compare 132 children conceived spontaneously to see if ART can influent on the health status in future
To identify the indicators of cellular and humoral immunity in children born after different oocyte fertilization methods in IVF programs classical IVF or ICSI
To study the long-term effects of ART on the endocrine status of children
It will be studied hemogram examination immunity indicators cellular components CD3 CD4 CD8 CD16 CD20 CD25 CD95 CD3 HLA DR CD HLA-DR humoral components - IgM IgA IgE IgG and laboratory investigations in endocrine system TSH free T3 and T4 levels insulin insulin-like growth factor-1 IGF-1 somatotropic hormone STH glucose potassium sodium in 120 children born after ART Researchers will compare 132 children conceived spontaneously to see if ART can influent on the health status in future
Detailed Description:
The tasks of the planned scientific and engineering project are based on the study of health status of children born after ART The presence of a large cohort of children after ART in Kazakhstan will allow us to study morbidity patterns with the connection of mothers anamnesis as well as to develop a prediction model and algorithms for the management of children conceived by assisted pregnancy A comprehensive assessment of the health status of children born after ART will make it possible to determine the effect of the method of conception on the risks of immunity-related diseases and endocrine system pathology It will allow us to predict deviations and ensure timely access to specialists and further examination The presence of a burdened psychological background in couples with infertility may further influence the psychosocial adaptation of children conceived by ART andor provoke higher morbidity rates in this group of children It is important for the healthy and full integration of these children into society including successful professional development in the future
22 The project objective to study the features of psychophysical development and the morbidity patterns of children born after assisted pregnancy and to identify the connection with the health status of mothers followed by the development of a prediction model and general principles of management of children born after ART
Project Tasks
1 To study the influence of premorbid background of mothers on childrens physical development disease occurrence and morbidity patterns of children based on a retrospective study of 120 medical records of mothers and their children born as after ART
2 To determine the indicators of cellular and humoral immunity hemogram examination cellular components CD3 CD4 CD8 CD16 CD20 CD25 CD95 CD3 HLA DR CD HLA-DR humoral components - IgM IgA IgE IgG in children born after ART
3 To study the long-term effects of the hormone therapy in 120 mothers on the endocrine status TSH free T3 and T4 levels insulin insulin-like growth factor-1 IGF-1 somatotropic hormone STH glucose potassium sodium of children born after ART
4 To develop a prediction model and algorithms for the management of children born after ART
22 The project objective to study the features of psychophysical development and the morbidity patterns of children born after assisted pregnancy and to identify the connection with the health status of mothers followed by the development of a prediction model and general principles of management of children born after ART
Project Tasks
1 To study the influence of premorbid background of mothers on childrens physical development disease occurrence and morbidity patterns of children based on a retrospective study of 120 medical records of mothers and their children born as after ART
2 To determine the indicators of cellular and humoral immunity hemogram examination cellular components CD3 CD4 CD8 CD16 CD20 CD25 CD95 CD3 HLA DR CD HLA-DR humoral components - IgM IgA IgE IgG in children born after ART
3 To study the long-term effects of the hormone therapy in 120 mothers on the endocrine status TSH free T3 and T4 levels insulin insulin-like growth factor-1 IGF-1 somatotropic hormone STH glucose potassium sodium of children born after ART
4 To develop a prediction model and algorithms for the management of children born after ART
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None