Ignite Creation Date:
2024-05-06 @ 7:40 PM
Last Modification Date:
2024-10-26 @ 3:11 PM
Study NCT ID:
NCT06097546
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-10-24
First Post:
2023-10-07
Brief Title:
Serum Retinoic Acid Induced Protein 14 RAI14 and Metastasis Associated Cancer Colon -1 MACC-1 in Breast Cancer
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Evaluation of Serum Retinoic Acid Induced Protein 14 RAI14 and Metastasis Associated Cancer Colon -1 MACC-1 as Biomarkers for Breast Cancer
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 Measurement of serum levels of Retinoic acid induced 14 RAI14 and Metastasis associated cancer colon -1 MACC-1 as biomarkers for diagnosis of breast cancer
2 Study their relationship to disease stages and clinicopathological features of BC
3 Compare the diagnostic performance of serum RAI14 and serum MACC-1 with serum Carcinoembryonic antigen CEA and Cancer antigen 15-3 CA15-3 for diagnosis of BC
2 Study their relationship to disease stages and clinicopathological features of BC
3 Compare the diagnostic performance of serum RAI14 and serum MACC-1 with serum Carcinoembryonic antigen CEA and Cancer antigen 15-3 CA15-3 for diagnosis of BC
Detailed Description:
Breast cancer BC is one of the most prevalent Neoplasms and the second leading reason of death from cancer in women Every year approximately 23 million new cases of BC are diagnosed worldwide Due to the high impact of this type of cancer the early detection early diagnosis and effective treatment will improve the diagnosis of patients and lower the associated mortality rates Carcinoembryonic antigen CEA and Cancer antigen 15-3 CA15-3 are the most commonly used serum markers in the diagnosis and follow up of BC However their clinical applications still remain controversial
Retinoic acid induced protein 14 RAI14 is an actin-binding protein which participates in physiological processes such as the regulation of cell polarity and transport of spermatozoa Recent studies showed that RAI14 is overexpressed in several malignant tumors with a significant role in the development of tumors The serum RAI14 is a reliable novel marker in the early diagnosis and chemotherapy monitoring of triple-negative BC
Metastasis-associated colon cancer-1 MACC-1 is a newly identified tumor marker first identified in colon cancer tissue as a prognostic indicator and inducer of metastasis It is located on human chromosome 7 7p211 and shown to be a key regulator of the hepatocyte growth factor-mesenchymal epithelial transition factor HGF-MET pathway in colon cancer It is shown that serum MACC-1 can be a potential biomarker for diagnosis and progression in patients with BC There was a strong correlation between MACC-1 expression and the clinical and the primary tumor regional nodes metastasis TNM stages of BC
Retinoic acid induced protein 14 RAI14 is an actin-binding protein which participates in physiological processes such as the regulation of cell polarity and transport of spermatozoa Recent studies showed that RAI14 is overexpressed in several malignant tumors with a significant role in the development of tumors The serum RAI14 is a reliable novel marker in the early diagnosis and chemotherapy monitoring of triple-negative BC
Metastasis-associated colon cancer-1 MACC-1 is a newly identified tumor marker first identified in colon cancer tissue as a prognostic indicator and inducer of metastasis It is located on human chromosome 7 7p211 and shown to be a key regulator of the hepatocyte growth factor-mesenchymal epithelial transition factor HGF-MET pathway in colon cancer It is shown that serum MACC-1 can be a potential biomarker for diagnosis and progression in patients with BC There was a strong correlation between MACC-1 expression and the clinical and the primary tumor regional nodes metastasis TNM stages of BC
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None