Ignite Creation Date:
2024-05-06 @ 7:40 PM
Last Modification Date:
2024-10-26 @ 3:11 PM
Study NCT ID:
NCT06096740
Status:
RECRUITING
Last Update Posted:
2024-07-09
First Post:
2023-10-17
Brief Title:
Psychotherapy Effects on Reward Processing in PTSD
Sponsor:
University of Texas at Austin
Organization:
University of Texas at Austin
Study Overview
Official Title:
The Effects of Trauma-focused Psychotherapy on Reward Circuitry Function and Information Encoding
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PERPP
Brief Summary:
The purpose of this study is to identify how trauma-focused psychotherapy changes the function of brain circuitry in posttraumatic stress disorder PTSD and how this mediates improvements in the diminished ability to experience positive emotions following a traumatic or extremely stressful life event In this instance the investigators will be using cognitive processing therapy CPT a widely-utilized and evidence-based treatment for PTSD
Detailed Description:
The goals of the study are as follows
1 Quantify under conditions of safety no threat how PTSD psychotherapy alters reward circuit function and information encoding
2 Identify how presence of threat augments PTSD psychotherapy effects on reward circuit function and information encoding
3 Exploratory Identify how following psychotherapy changes in reward circuit function and information encoding under conditions of safety and threat are associated with improvements in symptoms of diminished positive affect DimPA
To accomplish the goals of the study the investigators propose a neuroimaging-coupled randomized clinical trial of immediate vs delayed individual cognitive processing therapy CPT in individuals N120 with a primary diagnosis of chronic PTSD Individuals will undergo prior to randomization clinical and neurobiological assessment with functional magnetic resonance imaging fMRI during completion of several reward processing paradigms Two of these involve both a normal safe context and a threat context manipulation threat of mild electrodermal shock that is periodically cycled throughout the task Another paradigm involves making decisions to either approach reward or forego a reward when this decision conflicts with the likelihood of an aversive outcome This is known as approach-avoidance conflict AAC This battery will provide a comprehensive characterization of reward processing behavior and circuit function and establish its relationship to treatment processes as well as how such processes may vary as a function of threat
1 Quantify under conditions of safety no threat how PTSD psychotherapy alters reward circuit function and information encoding
2 Identify how presence of threat augments PTSD psychotherapy effects on reward circuit function and information encoding
3 Exploratory Identify how following psychotherapy changes in reward circuit function and information encoding under conditions of safety and threat are associated with improvements in symptoms of diminished positive affect DimPA
To accomplish the goals of the study the investigators propose a neuroimaging-coupled randomized clinical trial of immediate vs delayed individual cognitive processing therapy CPT in individuals N120 with a primary diagnosis of chronic PTSD Individuals will undergo prior to randomization clinical and neurobiological assessment with functional magnetic resonance imaging fMRI during completion of several reward processing paradigms Two of these involve both a normal safe context and a threat context manipulation threat of mild electrodermal shock that is periodically cycled throughout the task Another paradigm involves making decisions to either approach reward or forego a reward when this decision conflicts with the likelihood of an aversive outcome This is known as approach-avoidance conflict AAC This battery will provide a comprehensive characterization of reward processing behavior and circuit function and establish its relationship to treatment processes as well as how such processes may vary as a function of threat
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None