Ignite Creation Date:
2024-05-06 @ 7:39 PM
Last Modification Date:
2024-10-26 @ 3:11 PM
Study NCT ID:
NCT06089096
Status:
RECRUITING
Last Update Posted:
2023-10-18
First Post:
2023-10-12
Brief Title:
Sleep Apnea and Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
Sponsor:
The University of Hong Kong
Organization:
The University of Hong Kong
Study Overview
Official Title:
Exploring the Association of Sleep Apnea With Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
Status:
RECRUITING
Status Verified Date:
2023-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Obstructive sleep apnea OSA is recurrent episodes of partial or complete obstruction of the upper airway during sleep that causes intermittent hypoxia and sleep fragmentation and leads to cardiometabolic and neurocognitive sequelae Chronic intermittent hypoxia sleep fragmentation of OSA and insufficient sleep have been significantly associated with higher risks of neurocognitive impairment including mild cognitive impairment MCI and Alzheimers disease Thus sleep and circadian function might be modifiable neurocognitive impairment factors
The significance of the study is to understand the relationships of MCI with sleep apnea and sleep-related symptoms which helps pave the groundwork for further research
The significance of the study is to understand the relationships of MCI with sleep apnea and sleep-related symptoms which helps pave the groundwork for further research
Detailed Description:
Obstructive sleep apnea OSA is recurrent episodes of partial or complete obstruction of the upper airway during sleep that causes intermittent hypoxia and sleep fragmentation Chronic intermittent hypoxia sleep fragmentation of OSA and insufficient sleep have been significantly associated with higher risks of neurocognitive impairment including mild cognitive impairment MCI and Alzheimers disease Thus sleep and circadian function might be modifiable neurocognitive impairment factors
A recent review of 11 studies involving 5826 subjects 96 with OSA and 9 with MCI or Alzheimers disease suggests OSA is a modifiable risk factor for cognitive decline Thus improving sleep sleep apnea and circadian function could be a high-value intervention target to alleviate cognitive impairment and decline in subjects with MCI
The study aims to understand the relationships of prevalent sleep apnea and sleep-related symptoms with neurocognitive status in patients who presented with the main complaint of neurocognitive impairment to the Memory clinic The information would help pave the groundwork for further research
A recent review of 11 studies involving 5826 subjects 96 with OSA and 9 with MCI or Alzheimers disease suggests OSA is a modifiable risk factor for cognitive decline Thus improving sleep sleep apnea and circadian function could be a high-value intervention target to alleviate cognitive impairment and decline in subjects with MCI
The study aims to understand the relationships of prevalent sleep apnea and sleep-related symptoms with neurocognitive status in patients who presented with the main complaint of neurocognitive impairment to the Memory clinic The information would help pave the groundwork for further research
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None