Ignite Creation Date:
2024-05-06 @ 7:39 PM
Last Modification Date:
2024-10-26 @ 3:11 PM
Study NCT ID:
NCT06088108
Status:
RECRUITING
Last Update Posted:
2023-10-18
First Post:
2023-10-04
Brief Title:
Metabolic Responses to Exercise and Recovery
Sponsor:
University College London
Organization:
University College London
Study Overview
Official Title:
Age and Sex Differences in the Metabolic Response to Exercise
Status:
RECRUITING
Status Verified Date:
2023-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Exercise benefits health through diverse metabolic processes and is central to healthy ageing However intense exercise also challenges the body causing cellular damage that must be repaired This means that we need to identify the level of exercise that can optimise health and this level might potentially differ by age and sex Our research aims to tackle this question by studying the metabolic responses of the body both to exercise and during the subsequent recovery in 48 healthy and active participants between the ages of 8-10 23-27 and 53-57
Participants will complete an inclusion questionnaire and if eligible be invited to visit the exercise laboratory 4-5-hours We will collect questionnaire data and body measurements before participants undertake exercise on a treadmill Biological samples blood from adults only and saliva from everyone will be collected at three time points before right after and one hour after exercise
Participants will complete an inclusion questionnaire and if eligible be invited to visit the exercise laboratory 4-5-hours We will collect questionnaire data and body measurements before participants undertake exercise on a treadmill Biological samples blood from adults only and saliva from everyone will be collected at three time points before right after and one hour after exercise
Detailed Description:
Before taking part participants will be asked to complete an online inclusion questionnaire where the investigators will ask some questions about their health status weight status lifestyle and medications to confirm that the participants are eligible and that it is safe for the participants to participate in the study The investigators will record their consent electronically at this stage If the participants are eligible and decide to take part in the study the investigators will ask the participants to record their consent in writing before proceeding further
The in-person part of the study will take place at the University Of East London SportsDock 4-6 University Way London E16 2RD and last 4-5 hours No breakfast or coffeetea should be consumed on the day of the visit but the investigators will offer the participants breakfast The participants will also need to not have had any alcohol recreational drugs or exercise for 24 hours
On the day the investigators will first measure their resting heart rate and blood pressure collect body measurements weight height waist circumference hip circumference and measure their body composition The last thing the investigators will do before breakfast is to collect some samples The investigators will collect two separate saliva samples using synthetic cotton swabs After this the investigators will collect a blood sample by venepuncture needle prick from the adults only This first part of the study will take 45-60 minutes
Along with breakfast the investigators will ask the participants to consume a dose of deuterium-labelled water an odourless tasteless and safe water that will allow us to measure their total body water content The investigators will also ask the participants to complete two short questionnaires assessing their mood appetite feeling of tiredness as well as verbal learning This part will take approximately 30 minutes
The researcher will then help the participants familiarise with the treadmill and associated equipment The participants will wear a chest strap under their clothes and a special face mask which will be held in place by a head strap These will measure their heart rate and everything the participants breathe in and out throughout the exercise challenge respectively The treadmill will start slowly to help the participants warm up and familiarise with the feeling of walking on it After 2 minutes the exercise challenge will begin This will last for approximately 20 minutes during which the treadmill will increase the speed andor the incline every 2 minutes It will feel like the participants are walking more briskly and more uphill but it will not be too fast The researcher will encourage the participants to complete the exercise challenge as this will get the best response from their metabolism and give us the most accurate results The participants will be able to stop the treadmill if the participants feel too exhausted to continue feel faint or develop chest pain
Right after the participants complete the exercise challenge the investigators will collect a saliva sample using a synthetic cotton swab and a blood sample by venepuncture adults only The investigators will then ask the participants to complete the same two short questionnaires as before This part will take approximately 30 minutes
Finally the researcher will allow the participants to relax and rest for about an hour The investigators will then collect the last saliva samples using synthetic cotton swabs and blood samples by venepuncture adults only The participants will then complete the last iteration of the two short questionnaires
The in-person part of the study will take place at the University Of East London SportsDock 4-6 University Way London E16 2RD and last 4-5 hours No breakfast or coffeetea should be consumed on the day of the visit but the investigators will offer the participants breakfast The participants will also need to not have had any alcohol recreational drugs or exercise for 24 hours
On the day the investigators will first measure their resting heart rate and blood pressure collect body measurements weight height waist circumference hip circumference and measure their body composition The last thing the investigators will do before breakfast is to collect some samples The investigators will collect two separate saliva samples using synthetic cotton swabs After this the investigators will collect a blood sample by venepuncture needle prick from the adults only This first part of the study will take 45-60 minutes
Along with breakfast the investigators will ask the participants to consume a dose of deuterium-labelled water an odourless tasteless and safe water that will allow us to measure their total body water content The investigators will also ask the participants to complete two short questionnaires assessing their mood appetite feeling of tiredness as well as verbal learning This part will take approximately 30 minutes
The researcher will then help the participants familiarise with the treadmill and associated equipment The participants will wear a chest strap under their clothes and a special face mask which will be held in place by a head strap These will measure their heart rate and everything the participants breathe in and out throughout the exercise challenge respectively The treadmill will start slowly to help the participants warm up and familiarise with the feeling of walking on it After 2 minutes the exercise challenge will begin This will last for approximately 20 minutes during which the treadmill will increase the speed andor the incline every 2 minutes It will feel like the participants are walking more briskly and more uphill but it will not be too fast The researcher will encourage the participants to complete the exercise challenge as this will get the best response from their metabolism and give us the most accurate results The participants will be able to stop the treadmill if the participants feel too exhausted to continue feel faint or develop chest pain
Right after the participants complete the exercise challenge the investigators will collect a saliva sample using a synthetic cotton swab and a blood sample by venepuncture adults only The investigators will then ask the participants to complete the same two short questionnaires as before This part will take approximately 30 minutes
Finally the researcher will allow the participants to relax and rest for about an hour The investigators will then collect the last saliva samples using synthetic cotton swabs and blood samples by venepuncture adults only The participants will then complete the last iteration of the two short questionnaires
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None