Ignite Creation Date:
2024-05-06 @ 7:38 PM
Last Modification Date:
2024-10-26 @ 3:10 PM
Study NCT ID:
NCT06070883
Status:
COMPLETED
Last Update Posted:
2023-10-06
First Post:
2023-10-01
Brief Title:
Efficacy of Mutilayered Fresh Amnoitic Membrane Transplantation in Resistant Fungal Keratitis
Sponsor:
Al-Azhar University
Organization:
Al-Azhar University
Study Overview
Official Title:
Efficacy of Mutilayered Fresh Amnoitic Membrane Transplantation in Resistant Fungal Keratitis
Status:
COMPLETED
Status Verified Date:
2023-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Corneal infection or infectious keratitis IK is the most common cause of corneal blindness worldwide particu-larly in the developing countries1 The incidence was estimated at 25-799 per 100000 populationyear It is a painful and potentially blinding ocular emergency that often requires hospital admission for intensive medical andor surgical treatment Depending on the geographical and temporal variations and population-based risk factors eg agricultural practice trauma use of contact lens and others bacteria and fungi have been shown to be the main causative microorganisms for IK followed by viruses parasites and polymicrobial infection Amniotic membrane AM is the innermost layer of the placenta which consists of a single layer of meta-bolically active epithelium a thick basement membrane and an avascular stromal matrix 15
It has been shown to exhibit a wide array of biological properties including wound healing anti-inflammatory antimicrobial and anti-angiogenic properties amongst others To date a number of studies have evaluated the benefit of AMT for treating active IK though the majority of them were of small case series or case reports In clinical practice AMT is usually reserved as a second-line therapy in IK mainly to promote cornea healing in non-healing ulcer after the sterilization phase
It has been shown to exhibit a wide array of biological properties including wound healing anti-inflammatory antimicrobial and anti-angiogenic properties amongst others To date a number of studies have evaluated the benefit of AMT for treating active IK though the majority of them were of small case series or case reports In clinical practice AMT is usually reserved as a second-line therapy in IK mainly to promote cornea healing in non-healing ulcer after the sterilization phase
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None