Ignite Creation Date:
2024-05-06 @ 7:38 PM
Last Modification Date:
2024-10-26 @ 3:10 PM
Study NCT ID:
NCT06079437
Status:
COMPLETED
Last Update Posted:
2023-10-12
First Post:
2023-09-29
Brief Title:
The Effect of Brief Skin Cooling on Isometric Muscle Strength
Sponsor:
Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Organization:
Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Study Overview
Official Title:
The Effect of Brief Skin Cooling on Isometric Muscle Strength and the Neuronal Mechanism Underlying This Effect
Status:
COMPLETED
Status Verified Date:
2023-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
There is sympathetic innervation of the muscular spindle The application of cold to the skin provides an increase in sympathetic activity In rehabilitation practice short-term local cold is applied to the skin to provide motor facilitation The aim of this study was to examine whether short-term local cold application provides an increase in isometric contractile strength and if so whether this effect is related to muscle spindle activity
Detailed Description:
Cold application is frequently used in sports medicine and rehabilitation due to its beneficial effects on the neuromuscular system Its main beneficial effects are facilitating muscle contraction motor facilitation increasing isometric muscle force formation and reducing spasticity The motor effects of cold application may vary depending on the application time cooling agent ice ice water cooling spray etc and subcutaneous fatty tissue thickness Short-term cold application can increase contraction force through motor facilitation As the duration of cold application increases the effects of cold that inhibit motor functions such as gamma motor neuron inhibition muscle spindle inhibition and muscle conduction block come to the fore With this effect it is used in the treatment of spasticity
Neurophysiological studies to explain the motor effects of cold application have generally focused on the monosynaptic muscle spindle-based reflex The monosynaptic muscle spindle-based reflex activates muscle spindles and stimulates alpha motor neurons via Group Ia afferent nerves This effect is also known as the servo-motor servo-assistance effect of the muscle spindle The increase in the sensitivity of the muscle spindle can provide motor facilitation by strengthening the servo-assistance effect
It has been shown that the muscle spindle has sympathetic innervation It has been shown that the cold stress test can be an alternative to the classical autonomic nerve test and can be used to test sympathetic system activation Additionally studies have shown that cold stress test mental arithmetic isometric contraction and muscle ischemia cause an increase in muscle spindle sensitivity through increased sympathetic activity
A literature review has shown that there is no study examining the mechanism underlying the effect of local cold application on motor facilitation Demonstrating the effect of local cold application on increasing maximum contraction force through muscle spindle sensitivity is also important for clinical applications to be more effective and efficient The aim of this study was to examine whether short-term local cold application increases isometric contraction force and if there is an increase whether this effect is related to muscle spindle activity
Neurophysiological studies to explain the motor effects of cold application have generally focused on the monosynaptic muscle spindle-based reflex The monosynaptic muscle spindle-based reflex activates muscle spindles and stimulates alpha motor neurons via Group Ia afferent nerves This effect is also known as the servo-motor servo-assistance effect of the muscle spindle The increase in the sensitivity of the muscle spindle can provide motor facilitation by strengthening the servo-assistance effect
It has been shown that the muscle spindle has sympathetic innervation It has been shown that the cold stress test can be an alternative to the classical autonomic nerve test and can be used to test sympathetic system activation Additionally studies have shown that cold stress test mental arithmetic isometric contraction and muscle ischemia cause an increase in muscle spindle sensitivity through increased sympathetic activity
A literature review has shown that there is no study examining the mechanism underlying the effect of local cold application on motor facilitation Demonstrating the effect of local cold application on increasing maximum contraction force through muscle spindle sensitivity is also important for clinical applications to be more effective and efficient The aim of this study was to examine whether short-term local cold application increases isometric contraction force and if there is an increase whether this effect is related to muscle spindle activity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None