Ignite Creation Date:
2024-05-06 @ 7:37 PM
Last Modification Date:
2024-10-26 @ 3:10 PM
Study NCT ID:
NCT06078579
Status:
RECRUITING
Last Update Posted:
2024-02-06
First Post:
2023-09-27
Brief Title:
Salivary and Serum Leptin Levels in Oral Lichen Planus Patients A Case-control Study
Sponsor:
Cairo University
Organization:
Cairo University
Study Overview
Official Title:
Salivary and Serum Leptin Levels in Oral Lichen Planus Patients A Case-Control Study
Status:
RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to evaluate the levels of leptin in both saliva and serum samples of patients diagnosed with oral lichen
Detailed Description:
Oral lichen planus is a frequently encountered chronic muco-cutaneous condition with a high prevalence rate The condition can be classified as an autoimmune disorderAlthough the exact cause of this condition is unknown some potential risk factors should be taken into account such as systemic disorders psychogenic diseases dental restorations and certain medications
The oral lesions exhibit a mostly bilateral pattern often manifesting in the inner buccal mucosa The condition can be classified into three distinct forms namely the reticular form atrophic form and bullous-erosive form
The condition is classified as a premalignant lesion due to its significant likelihood of undergoing malignant transformation The disease is characterized by the presence of T-lymphocyte infiltration in the basal cell layer of the epithelium and the presence of cytoid bodies which are distinct histopathologic markers
Leptin a hormone generated by adipocytes is involved in immunological responses and contributes to the development of autoimmunity The presence of dyslipidemia has been found to be associated with lipoprotein LP abnormalities Consequently this study was undertaken to assess the blood leptin levels and lipid profile in individuals with LP Leptin a polypeptide hormone is produced and released by white adipose tissue
Multiple research have substantiated an increase in leptin levels among persons exhibiting elevated body mass index BMI and a higher percentage of total body fat Additionally it is involved in the cellular immune response and facilitates the development of autoimmunity
There is a proposition suggesting that leptin has a role in the promotion of cytokine generation and modulation of helper T cells potentially implicating its involvement in the pathogenesis of psoriasis The available information about leptin status in dermatological illnesses other than psoriasis is currently sparse It is plausible that it may have a significant role in the pathogenesis of lichen planus
However there is a lack of literature regarding the levels of leptin in LP There is an association between dyslipidemia and LP Numerous investigations have consistently demonstrated notable deviations in lipid profile levels between individuals with LP and those in normal healthy control cohorts These findings have led researchers to posit a correlation between chronic inflammation and dyslipidemia hence heightening the susceptibility to cardiovascular illnesses
The potential impact of leptin on the progression of LP is being investigated The objective of this study was to conduct a comparative analysis of blood leptin levels between individuals recently diagnosed with LP and a control group consisting of healthy individuals Additionally an assessment was conducted to examine the correlation between leptin levels lipid profile and the length of illness
The oral lesions exhibit a mostly bilateral pattern often manifesting in the inner buccal mucosa The condition can be classified into three distinct forms namely the reticular form atrophic form and bullous-erosive form
The condition is classified as a premalignant lesion due to its significant likelihood of undergoing malignant transformation The disease is characterized by the presence of T-lymphocyte infiltration in the basal cell layer of the epithelium and the presence of cytoid bodies which are distinct histopathologic markers
Leptin a hormone generated by adipocytes is involved in immunological responses and contributes to the development of autoimmunity The presence of dyslipidemia has been found to be associated with lipoprotein LP abnormalities Consequently this study was undertaken to assess the blood leptin levels and lipid profile in individuals with LP Leptin a polypeptide hormone is produced and released by white adipose tissue
Multiple research have substantiated an increase in leptin levels among persons exhibiting elevated body mass index BMI and a higher percentage of total body fat Additionally it is involved in the cellular immune response and facilitates the development of autoimmunity
There is a proposition suggesting that leptin has a role in the promotion of cytokine generation and modulation of helper T cells potentially implicating its involvement in the pathogenesis of psoriasis The available information about leptin status in dermatological illnesses other than psoriasis is currently sparse It is plausible that it may have a significant role in the pathogenesis of lichen planus
However there is a lack of literature regarding the levels of leptin in LP There is an association between dyslipidemia and LP Numerous investigations have consistently demonstrated notable deviations in lipid profile levels between individuals with LP and those in normal healthy control cohorts These findings have led researchers to posit a correlation between chronic inflammation and dyslipidemia hence heightening the susceptibility to cardiovascular illnesses
The potential impact of leptin on the progression of LP is being investigated The objective of this study was to conduct a comparative analysis of blood leptin levels between individuals recently diagnosed with LP and a control group consisting of healthy individuals Additionally an assessment was conducted to examine the correlation between leptin levels lipid profile and the length of illness
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None