Ignite Creation Date:
2024-05-06 @ 7:36 PM
Last Modification Date:
2024-10-26 @ 3:10 PM
Study NCT ID:
NCT06065930
Status:
RECRUITING
Last Update Posted:
2023-10-04
First Post:
2023-07-11
Brief Title:
Adaptive Mechanisms In GRown up ObeSity Study AMIGROS
Sponsor:
Vastra Gotaland Region
Organization:
Vastra Gotaland Region
Study Overview
Official Title:
Mechanistic Studies in Human Subcutaneous Adipose Tissue
Status:
RECRUITING
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
AMIGROS
Brief Summary:
The investigator recently showed that the glycan-binding adipokine galectin-1 increased during overfeeding and that galectin-1 independently could predict type 2 diabetes Further the molecules that induce insulin release in the fasting state when blood glucose is normal remain elusive It is possible that galectin-1 is involved in adaptive mechanisms in adipose tissue in obese subjects
Detailed Description:
The investigator will define adaptive mechanisms in adipose tissue associated with galectin-1 in obese insulin-sensitive Ob-IS subjects compared with obese insulin-resistant Ob-IR subjects and lean healthy controls Further the investigator will study molecules secreted from adipose tissue that might trigger insulin secretion when blood glucose is normal
The investigator hypothesizes that Ob-IS subjects keep fatty acid levels normal through an adaptive response in adipose tissue that involves up-regulation of galectin-1 for dampening of immune cell activity and stimulation of lipolysis
The investigator hypothesizes that Ob-IS subjects keep fatty acid levels normal through an adaptive response in adipose tissue that involves up-regulation of galectin-1 for dampening of immune cell activity and stimulation of lipolysis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None