Ignite Creation Date:
2024-05-06 @ 7:35 PM
Last Modification Date:
2024-10-26 @ 3:09 PM
Study NCT ID:
NCT06064370
Status:
COMPLETED
Last Update Posted:
2024-06-11
First Post:
2023-09-26
Brief Title:
Side-specific Factors for Intraoperative Hemodynamic Instability in Pheochromocytoma
Sponsor:
Zagazig University
Organization:
Zagazig University
Study Overview
Official Title:
Side-specific Factors for Intraoperative Hemodynamic Instability in Adrenalectomy for Pheochromocytoma A Comparative Analysis
Status:
COMPLETED
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The performance of adrenalectomy for pheochromocytoma PHEO presents significant challenges due to the presence of elevated intraoperative hemodynamic instability HI and conversion risk The objective of this study was to conduct a comparative analysis of the occurrence and determinants of perioperative hypotension HI and conversion in left-sided LLA and right-sided RLA transabdominal laparoscopic adrenalectomy TLA
Detailed Description:
Pheochromocytoma PHEO is a malignancy characterized by the production of catecholamines from chromaffin cells located in the adrenomedullary system The prevalence of PHEO in the general population ranges from 005 to 01 however it is more prevalent among those with hypertension The clinical presentation exhibits a spectrum that spans from asymptomatic to abrupt mortality Minimally invasive laparoscopic adrenalectomy LA has emerged as a prominent technique in adrenal illness surgery due to its reduced surgical morbidity and death rates making it the favored method in this field The initial exploration of transperitoneal laparoscopic adrenalectomy TLA was conducted by Gagner et al The LA procedure encompasses many transabdominal and retroperitoneal techniques whereas TLA is favored by surgeons due to its well-known anatomy and expansive working area Nevertheless PHEO surgery remains a formidable task for surgeons and anesthesiologists due to its established correlation with hemodynamic instability HI resulting in symptoms such as abrupt hypertension or tachycardia as well as severe and protracted hypotension following tumor excision Skilled surgeons and anesthesiologists enhance the outcomes and reduce the occurrence of hypotension The research has documented a multitude of additional risk factors associated with HI The observed variability could perhaps be attributed to the lack of consistent anesthesiological and surgical protocols as well as variations in the definitions of HI Laparoscopic adrenalectomy does not have any absolute contraindications However it is worth noting that up to 20 of patients may need to undergo conversion to an open procedure There has been no specific evaluation of the incidence and risk factors of perioperative hypotension both intraoperative and postoperative and conversion rate in a large group of patients undergoing laparoscopic right adrenalectomy LRA or laparoscopic left adrenalectomy LLA for managing pheochromocytoma resection
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None