Ignite Creation Date:
2024-05-06 @ 7:35 PM
Last Modification Date:
2024-10-26 @ 3:10 PM
Study NCT ID:
NCT06069427
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-05-08
First Post:
2023-09-27
Brief Title:
The Effect of Reducing Total Volume of Sprint Exercise on Circulating Levels of BDNF
Sponsor:
University of Stirling
Organization:
University of Stirling
Study Overview
Official Title:
The Effect of Reducing Total Volume of Sprint Exercise in Sprint Interval Training Protocols on Circulating Levels of Brain-derived Neurotrophic Factor BDNF
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Regular exercise is well known to be required for good physical health but exercise can also improve mental health Although the effects of exercise on mental health have been shown in many studies it remains unclear how exercise improves mental health In recent years the potential role of a specific protein called brain-derived neurotrophic factor BDNF has received increasing attention Higher levels of BDNF in the blood are associated with better cognitive performance attention and spatial memory Conversely low levels of BDNF in the blood are found in patients with depression dementia mild cognitive impairment and Alzheimers disease BDNF can be released during exercise with greater increases after exercise performed at higher intensities For example classic sprint interval training SIT which involves four 30-second all-out cycle sprints has been shown to lead to greater increases in BDNF compared to moderate or vigorous exercise Although these results suggest that SIT is an effective way to increase BDNF SIT is not generally considered feasible for patients or untrained members of the general public because it is a very tiring type of exercise However other more manageable protocols have been developed such as the reduced-exertion high-intensity interval training REHIT protocol which involves two 20-second all-out sprints within a 10-minute low-intensity exercise session Although it is clear that BDNF levels increase in an intensity-dependent manner in response to exercise the effect of exercise volume remains unknown Exercise intensity is identical for SIT and REHIT but if BDNF levels increase to a similar extent in response to both protocols REHIT would constitute a more feasible intervention for use in patients and the general public The aim of the present study is to compare the effects of REHIT vs classic SIT on levels of BDNF in the blood For this15 study participants will be recruited who will each complete a SIT session a REHIT session and a no-exercise control session Levels of BDNF will be measured in blood samples taken at rest as well as directly after exercise 30 minutes after exercise and 90 minutes after exercise It will be determined whether the greater amount of sprint exercise in a SIT session will be associated with a greater increase in levels of BDNF in the blood compared to the REHIT session which consists of a lower amount of sprint exercise
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None