Ignite Creation Date:
2024-05-06 @ 7:35 PM
Last Modification Date:
2024-10-26 @ 3:09 PM
Study NCT ID:
NCT06060808
Status:
COMPLETED
Last Update Posted:
2023-09-29
First Post:
2023-09-24
Brief Title:
Role of NFKBIA and PTPN22 Genes Polymorphism in Acute Rejection Susceptibility After Living Donor Liver Transplantation in Egyptian Patients
Sponsor:
Helwan University
Organization:
Helwan University
Study Overview
Official Title:
Role of NFKBIA and PTPN22 Genes Polymorphism in Acute Rejection Susceptibility After Living Donor Liver Transplantation in Egyptian Patients
Status:
COMPLETED
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Our study aimed at studying the impact of gene polymorphism of NFKBIA and PTPN22 genes on rejection episodes in liver transplant Egyptian recipients Also assess patients factors associated with graft rejection
Detailed Description:
Liver transplantation is considered an effective therapy for severe liver disease but graft dysfunction occurs in up to 13 of patients during the first year following transplantation and rises to 35 after 5 years Keeffe 1999 Yu et al 2001 Graft rejection is one of the major immunological complications following liver transplantation Zheng et al 2006
The nuclear factor of kappa light polypeptide gene enhancer B-cells inhibitor-alpha NFKBIA gene encodes a member of the nuclear factor-kappa-B inhibitor family Polymorphisms in this gene might be associated with a susceptibility to acute rejection episodes following liver transplantation as they may cause an increased activation level of the proinflammatory transcription factor nuclear factor of kappa light polypeptide gene enhancer in B-cells NFκB
NFκB translocates to the nucleus and promotes the expression of a panel of genes Karin and Ben-Neriah 2000 Some of these for example interleukin-2 interleukin-6 interleukin-12 or tumor necrosis factor-alpha play an important role in the pathogenesis of allograft rejection and the activation of the immune system in general Wei and Zheng 2003
The protein tyrosine phosphatase nonreceptor 22 gene PTPN22 encodes a strong T-cell regulator called lymphoid protein tyrosine phosphatase Previously PTPN22 was described as a susceptibility gene for autoimmunity because it contains single nucleotide polymorphisms SNPs associated with several autoimmune diseases One SNP rs24766011858GA has emerged as a particularly potent risk factor for autoimmunity We address the question whether PTPN22 polymorphismsare also associated with acute rejection after liver transplantation Dullin et al 2015
The nuclear factor of kappa light polypeptide gene enhancer B-cells inhibitor-alpha NFKBIA gene encodes a member of the nuclear factor-kappa-B inhibitor family Polymorphisms in this gene might be associated with a susceptibility to acute rejection episodes following liver transplantation as they may cause an increased activation level of the proinflammatory transcription factor nuclear factor of kappa light polypeptide gene enhancer in B-cells NFκB
NFκB translocates to the nucleus and promotes the expression of a panel of genes Karin and Ben-Neriah 2000 Some of these for example interleukin-2 interleukin-6 interleukin-12 or tumor necrosis factor-alpha play an important role in the pathogenesis of allograft rejection and the activation of the immune system in general Wei and Zheng 2003
The protein tyrosine phosphatase nonreceptor 22 gene PTPN22 encodes a strong T-cell regulator called lymphoid protein tyrosine phosphatase Previously PTPN22 was described as a susceptibility gene for autoimmunity because it contains single nucleotide polymorphisms SNPs associated with several autoimmune diseases One SNP rs24766011858GA has emerged as a particularly potent risk factor for autoimmunity We address the question whether PTPN22 polymorphismsare also associated with acute rejection after liver transplantation Dullin et al 2015
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None