Ignite Creation Date:
2024-05-06 @ 7:34 PM
Last Modification Date:
2024-10-26 @ 3:09 PM
Study NCT ID:
NCT06053320
Status:
RECRUITING
Last Update Posted:
2023-09-25
First Post:
2023-09-01
Brief Title:
Spatial-Motor Stroke-Rehab Study
Sponsor:
Emory University
Organization:
Emory University
Study Overview
Official Title:
Novel Spatial-Motor Approaches to Improve Spatial Neglect and Walking Deficits Post-Stroke
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to understand how prism adaptation training with and without electrical stimulation changes visuospatial behavior motor system neurophysiology and walking dysfunction
Detailed Description:
Spatial Neglect SN is defined as pathological asymmetric spatial behavior causing functional disability and occurs in greater than 50 of individuals with right hemisphere stroke SN post-stroke is associated with increased fall risk increased hospital length of stay poorer rehabilitation outcomes and severe long-term disability Prism adaptation therapy PAT is an evidence-based treatment for SN after stroke however the effects of SN on gait are not well known Neuromuscular electrical stimulation delivered via surface electrodes is a common therapeutic adjunct in stroke rehabilitation including for SN and gait training However the additive therapeutic effects of combining electrical stimulation and PAT as well as the effects of motor training on gait deficits associated with SN are poorly understood Furthermore although there is limited literature examining the effects of electrical stimulation on corticospinal tract output CST there is an inadequate understanding of the neural mechanisms of PAT and the combinatorial effects of PAT with electrical stimulation To parse out the neural mechanisms of PAT and electrical stimulation on the visuospatial system researchers will first examine the effects of PAT with or without electrical stimulation in neurologically unimpaired adults researchers will then compare results to individuals with stroke with spatial neglect
The primary objective is to study the effects of PAT on visuospatial behavior and motor cortical excitability in able-bodied individuals young and older and on spatial neglect motor cortical neurophysiology and walking function in individuals post-stroke
The long-term goal of this project is to develop novel effective and personalized rehabilitation protocols targeting SN deficits and gait dysfunction to reduce disability in stroke survivors The rationale of this project is to explore and generate data regarding future novel combinatorial motor-spatial retraining approaches that will enhance the rehabilitation approach of SN and gait performance in individuals post-stroke
The primary objective is to study the effects of PAT on visuospatial behavior and motor cortical excitability in able-bodied individuals young and older and on spatial neglect motor cortical neurophysiology and walking function in individuals post-stroke
The long-term goal of this project is to develop novel effective and personalized rehabilitation protocols targeting SN deficits and gait dysfunction to reduce disability in stroke survivors The rationale of this project is to explore and generate data regarding future novel combinatorial motor-spatial retraining approaches that will enhance the rehabilitation approach of SN and gait performance in individuals post-stroke
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
True
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1F31NS131020-01 | NIH | None | httpsreporternihgovquickSearch1F31NS131020-01 |