Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005755
Status:
COMPLETED
Last Update Posted:
2016-03-16
First Post:
2000-05-25
Brief Title:
Community Based Study on Occupational Asthma
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2006-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To examine the occupations industries and exposures in the work-place which were associated with a high risk for asthma and other adverse respiratory health effects with particular emphasis on specific exposures of predominantly female occupations irritants detergents and other asthmagens and of other high risk major occupations which had not been adequately examined
Detailed Description:
BACKGROUND
Respiratory diseases are strongly related with exposure in the workplace A considerable proportion of adult onset asthma is associated with these exposures The importance of occupational risk factors for asthma has been underestimated particularly among women The occupational asthma study ECRHS-OA forms part of a wider international multicentre survey on respiratory health European Community Respiratory Health Survey-ECRHS The first phase of the ECRHS was conducted in 199192 and examined risk factors for asthma and atopy in subjects aged 20-44 years The study updated ECRHS-II following-up approximately 17000 young adults from 12 countries Australia Belgium France Germany Iceland Italy Norway Spain Sweden Switzerland UK and USA
The study provided valid and precise estimates on the importance of specific occupations industries and exposures in relation to asthma incidence and prevalence similar estimates for other respiratory symptoms and diseases and also for declines in pulmonary function
DESIGN NARRATIVE
Longitudinal community-based multicenter study Those subjects who took part in the first occupational asthma study survey were re-contacted in 1999 to determine risk factors for incidence and remission of asthma other respiratory symptoms atopy changes in bronchial responsiveness and lung function Subjects were asked to perform a forced spirometry methacholine challenge and to provide blood samples for IgE testing A questionnaire administrated by trained interviewers was delivered requesting information on respiratory symptoms and diseases socio-demographic factors tobacco smoking complete occupational history since the last survey environmental exposures family history diet treatment and use of health services Modular occupational questionnaires were developed for subjects employed as cleaners homemakers welders metal workers nurses and subjects exposed to organic dusts in the paper and textile industries
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Respiratory diseases are strongly related with exposure in the workplace A considerable proportion of adult onset asthma is associated with these exposures The importance of occupational risk factors for asthma has been underestimated particularly among women The occupational asthma study ECRHS-OA forms part of a wider international multicentre survey on respiratory health European Community Respiratory Health Survey-ECRHS The first phase of the ECRHS was conducted in 199192 and examined risk factors for asthma and atopy in subjects aged 20-44 years The study updated ECRHS-II following-up approximately 17000 young adults from 12 countries Australia Belgium France Germany Iceland Italy Norway Spain Sweden Switzerland UK and USA
The study provided valid and precise estimates on the importance of specific occupations industries and exposures in relation to asthma incidence and prevalence similar estimates for other respiratory symptoms and diseases and also for declines in pulmonary function
DESIGN NARRATIVE
Longitudinal community-based multicenter study Those subjects who took part in the first occupational asthma study survey were re-contacted in 1999 to determine risk factors for incidence and remission of asthma other respiratory symptoms atopy changes in bronchial responsiveness and lung function Subjects were asked to perform a forced spirometry methacholine challenge and to provide blood samples for IgE testing A questionnaire administrated by trained interviewers was delivered requesting information on respiratory symptoms and diseases socio-demographic factors tobacco smoking complete occupational history since the last survey environmental exposures family history diet treatment and use of health services Modular occupational questionnaires were developed for subjects employed as cleaners homemakers welders metal workers nurses and subjects exposed to organic dusts in the paper and textile industries
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL062633 | NIH | None | httpsreporternihgovquickSearchR01HL062633 |