Ignite Creation Date:
2024-05-06 @ 7:33 PM
Last Modification Date:
2024-10-26 @ 3:09 PM
Study NCT ID:
NCT06058897
Status:
RECRUITING
Last Update Posted:
2024-04-30
First Post:
2023-06-22
Brief Title:
MRI and Eye-tracking Predictive Markers of Cognitive Ageing
Sponsor:
University Hospital Toulouse
Organization:
University Hospital Toulouse
Study Overview
Official Title:
Cerebral MRI Markers and Oculomotor Indices in Human Ageing Potential Predictors of Cognitive Maintenance or Decline
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PrediCog
Brief Summary:
This research proposes to investigate physiological and cognitive markers of locus coeruleus LC neuronal integrity and function in cognitively-healthy participants over 60 years old The locus coeruleus is a brainstem nucleus sole source of noradrenaline for the brain Tau pathology appears in neurons of this nucleus which may induce initial cognitive changes The study aims at relating locus coeruleus markers assessed with MRI and eye-tracking techniques with cognitive function
Detailed Description:
The LC is a small brainstem nucleus sole source of noradrenaline NA to the brain NA is involved in the physiological arousal response LC neuronal activity is closely related with pupil dilation and pupil size is now considered a reliable and easy-access biomarker of LC function NA-dependent cognitive functions include attention flexibility and memory which are selectively impaired with age Accordingly LC-NA system dysfunction may occur and contribute to initial cognitive changes during old age
The study will assess in cognitively-healthy older volunteers from the INSPIRE cohort n100 over 60 years old MRI and pupillometry markers of LC integrity LC-forebrain connectivity and LC activity We aim at investigating the relationship between LC biomarkers and cognitive status Four experimental visits will be conducted by each participant every 6 months over an 18-month period Visits V1 and V4 will include MRI eye-tracking and detailed cognitive exams Visits V2 and V3 will include a detailed cognitive exam
The study will assess in cognitively-healthy older volunteers from the INSPIRE cohort n100 over 60 years old MRI and pupillometry markers of LC integrity LC-forebrain connectivity and LC activity We aim at investigating the relationship between LC biomarkers and cognitive status Four experimental visits will be conducted by each participant every 6 months over an 18-month period Visits V1 and V4 will include MRI eye-tracking and detailed cognitive exams Visits V2 and V3 will include a detailed cognitive exam
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None