Ignite Creation Date:
2024-05-06 @ 7:33 PM
Last Modification Date:
2024-10-26 @ 3:09 PM
Study NCT ID:
NCT06055634
Status:
RECRUITING
Last Update Posted:
2023-09-28
First Post:
2023-09-20
Brief Title:
SIRT1rs7069102 Gene Polymorphism in Chronic Obstructive Pulmonary Disease at Egyptian Patients
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
SIRT1rs7069102 Gene Polymorphism in Chronic Obstructive Pulmonary Disease at Egyptian Patients
Status:
RECRUITING
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Chronic obstructive pulmonary disease COPD prevalence morbidity and mortality vary across countries and across different groups within countries with a direct relation to the prevalence of tobacco smoking Other risk factors for COPD include genetic factors longstanding asthma outdoor air pollution second-hand smoke exposure biomass smoke indoor air pollution occupational exposures and tuberculosis The prevalence and burden of COPD are projected to increase in the coming decades because of continued exposure to COPD risk factors and the changing age structure of the worlds population As these factors are rapidly increasing in developing countries COPD will become a major health problem exerting a huge demand on economic and healthcare resources in developing countries 2 In Egypt although COPD is a rising significant health problem data on its prevalence morbidity and mortality are still lacking and have to be estimated
Sirtuin 1 SIRT1 is a proteinhistone deacetylase dependent NAD It plays a crucial role in various human diseases such as cardiovascular diseases cancer inflammation aging neurodegenerative disease obesity and type 2 diabetes Seven isoforms of the SIRT1 gene SIRT1- SIRT7 have been determined in mammals Expression of the SIRT1 gene is regulated by transcription factors such as CREB FOXO3 HIC1 NF-KB p53 PARP-2 and PPAR SIRT1
Sirtuin 1 SIRT1 is a proteinhistone deacetylase dependent NAD It plays a crucial role in various human diseases such as cardiovascular diseases cancer inflammation aging neurodegenerative disease obesity and type 2 diabetes Seven isoforms of the SIRT1 gene SIRT1- SIRT7 have been determined in mammals Expression of the SIRT1 gene is regulated by transcription factors such as CREB FOXO3 HIC1 NF-KB p53 PARP-2 and PPAR SIRT1
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None