Ignite Creation Date:
2024-05-06 @ 7:32 PM
Last Modification Date:
2024-10-26 @ 3:08 PM
Study NCT ID:
NCT06041360
Status:
RECRUITING
Last Update Posted:
2023-09-18
First Post:
2023-09-06
Brief Title:
Prevalence of Peripheral Neuropathy Among Patients With Auditory Neuropathy
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Prevalence of Peripheral Neuropathy Among Patients With Auditory Neuropathy
Status:
RECRUITING
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Auditory neuropathy dys-synchrony peri-synaptic audiopathy AN are terms used to describe a specific hearing disorder with a disturbed auditory neural response in presence of normal cochlear function Initially reported as early as the 1970s by Hinchcliffe et al after observation of the patients with normal hearing thresholds who had difficulty to detect the sounds especially in presence of background noise Auditory Neuropathy is characterized by five integral features that distinguish it from other types of hearing loss These are Variable audiometric results anywhere from normal hearing to Sensorineural hearing loss of any degree up to profound hearing loss showing unusual audiometric pattern Preserved outer hair cells OHCs responses such as otoacoustic emissions OAEs andor cochlear microphonics CM Altered neural processing such abnormal auditory brainstem responses ABRs with a reduced or absent wave V Poor speech perception with poor speech recognition score that seems out of proportion compared to their pure-tone detection thresholds absent stapedial reflexes to the ipsilateral and contralateral tone at a 110-dB hearing level
In 2008 it was found that AN does not represent a single disease entity but it is a heterogeneous disease category with a wide range of hearing loss types etiologies age and clinical manifestations hence the adoption of the term auditory neuropathy spectrum disorder ANSD by an International Newborn Hearing Screening Conference held in Italy following a comprehensive study of newborn hearing test results
The prevalence of ANSD is variable in published studies from 023 to 15 among hearing impaired individuals Regarding the underlying etiological factors auditory neuropathy can be congenital or acquired AN without the involvement of the neurological system has been termed as primary auditory neuropathy PAN
Peripheral neuropathy is not a constant finding in all patients with this hearing disorder AN may occur in the afferent pathway of acoustic nerve probably accompanied by the pathological changes of efferent nerve in the olivocochlear system inside the brainstem Our study is conducted to detect the prevalence of peripheral neuropathy among patients with auditory neuropathy spectrum disorder
In 2008 it was found that AN does not represent a single disease entity but it is a heterogeneous disease category with a wide range of hearing loss types etiologies age and clinical manifestations hence the adoption of the term auditory neuropathy spectrum disorder ANSD by an International Newborn Hearing Screening Conference held in Italy following a comprehensive study of newborn hearing test results
The prevalence of ANSD is variable in published studies from 023 to 15 among hearing impaired individuals Regarding the underlying etiological factors auditory neuropathy can be congenital or acquired AN without the involvement of the neurological system has been termed as primary auditory neuropathy PAN
Peripheral neuropathy is not a constant finding in all patients with this hearing disorder AN may occur in the afferent pathway of acoustic nerve probably accompanied by the pathological changes of efferent nerve in the olivocochlear system inside the brainstem Our study is conducted to detect the prevalence of peripheral neuropathy among patients with auditory neuropathy spectrum disorder
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None