Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001891
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Myocardial Contrast Echocardiography MCE to Check for Living and Working Heart Muscle
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Assessment of Myocardial Viability Utilizing Myocardial Contrast Echocardiography
Status:
COMPLETED
Status Verified Date:
2000-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Coronary artery disease CAD can cause poor blood flow and supply to the heart muscle It can result in irreversible damage to the heart muscle and poor function Before treating patients with heart disease it is important to know how well the heart is functioning Echocardiography is a diagnostic test that can measure heart function If part of the heart muscle is not working properly due to previous damage echocardiography can provide information about how much improvement can be expected after treatment surgery or angioplasty
The purpose of this study is to compare the accuracy of myocardial contrast echocardiography MCE to dobutamine echocardiography to detect the potential for damaged heart muscle to be treated and function in patients with heart disease
Myocardial contrast echocardiography MCE does not use radioactivity It uses sound waves like standard echocardiography However with MCE patients receive an injection of a contrast agent directly into the blood stream through a vein The contrast agent called Optison is made of tiny microbubbles smaller than red blood cells The echocardiogram can detect these microbubbles in the small blood vessels of the heart muscle and allow researchers to find areas of the heart receiving less blood flow than others
Echocardiography with Dobutamine does not use radioactivity It uses sound waves like standard echocardiography During this echocardiogram patients receive doses of a medication called dobutamine that stimulates the heart to beat stronger and faster Heart muscle that does not beat stronger after dobutamine is probably dead usually as a result of a previous heart attack
The purpose of this study is to compare the accuracy of myocardial contrast echocardiography MCE to dobutamine echocardiography to detect the potential for damaged heart muscle to be treated and function in patients with heart disease
Myocardial contrast echocardiography MCE does not use radioactivity It uses sound waves like standard echocardiography However with MCE patients receive an injection of a contrast agent directly into the blood stream through a vein The contrast agent called Optison is made of tiny microbubbles smaller than red blood cells The echocardiogram can detect these microbubbles in the small blood vessels of the heart muscle and allow researchers to find areas of the heart receiving less blood flow than others
Echocardiography with Dobutamine does not use radioactivity It uses sound waves like standard echocardiography During this echocardiogram patients receive doses of a medication called dobutamine that stimulates the heart to beat stronger and faster Heart muscle that does not beat stronger after dobutamine is probably dead usually as a result of a previous heart attack
Detailed Description:
Dobutamine echocardiography has become a valuable technique for the evaluation of myocardial viability in patients with coronary artery disease CAD and dysfunctional myocardium because it can accurately predict which myocardial segments will show contractile recovery after successful revascularization Myocardial contrast echocardiography MCE offers the potential to evaluate tissue perfusion at the level where oxygen transfer to the myocytes occurs MCE therefore can provide information regarding the functional status of the myocardial microvasculature which has a close relationship with myocellular integrity The purpose of this study is to evaluate the accuracy of MCE compared to dobutamine echocardiography to detect myocardial viability in patients with CAD and resting wall motion abnormalities
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 99-H-0108 | None | None | None |