Ignite Creation Date:
2024-05-06 @ 7:31 PM
Last Modification Date:
2024-10-26 @ 3:08 PM
Study NCT ID:
NCT06040905
Status:
RECRUITING
Last Update Posted:
2024-02-07
First Post:
2023-09-04
Brief Title:
Causal Effect of Coenzyme Q10 Nutrition and Cognitive Dysfunction in the Metabolic Storm Hyperglycemia and Sarcopenia and Brain-derived Neurotrophic Factor
Sponsor:
Chung Shan Medical University
Organization:
Chung Shan Medical University
Study Overview
Official Title:
Causal Effect of Coenzyme Q10 Nutrition and Cognitive Dysfunction in the Metabolic Storm Hyperglycemia and Sarcopenia and Brain-derived Neurotrophic Factor
Status:
RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of the study is to investigate the effect of coenzyme Q10 supplementation 150 mgbid 300 mgd 12 weeks on coenzyme Q10 glucose parameters BDNF myokines and cognitive function in mild cognitive impairment MCI and Alzheimers disease AD patients who combined with hyperglycemia but without sarcopenia or with hyperglycemia and pre-sarcopenia
Detailed Description:
Alzheimers disease AD is an aging-related disease and is considered to be a type 3 diabetes Brain-derived neurotrophic factor BDNF is a potential therapeutic biomarker for AD Studies have found that antioxidant supplementation could elevate the level of BDNF Coenzyme Q10 is an antioxidant nutrient that participates in energy synthesis in mitochondria Studies have shown that coenzyme Q10 has the potential to regulate blood glucose However there are few clinical studies to examine the effects of coenzyme Q10 supplementation on glucose and muscular metabolism and BDNF status in AD This study will conduct an intervention study to understand the effect of coenzyme Q10 on BDNF and metabolic conditions hyperglycemia and pre-sarcopenia in patients with mild cognitive impairment MCI and AD The study will be designed as a randomized double-blind cross-over placebo-controlled study To investigate the effect of coenzyme Q10 supplementation 150 mgbid 300 mgd 12 weeks on coenzyme Q10 glucose parameters BDNF myokines and cognitive function in MCI and AD patients who combined with hyperglycemia but without sarcopenia or with hyperglycemia and pre-sarcopenia During the study demographic data mini-mental state examination anthropometric measurements dietary records nutritional and muscle function assessment quality of life and depression assessment will be collected Blood specimens will be also collected before and after the intervention then the levels of coenzyme Q10 BDNF oxidative stress antioxidant capacity myokines and mitochondrial function will be analyzed The study hopes to clarify the cause effects of coenzyme Q10 supplementation on the regulation of glucose and muscle metabolism and cognitive function in this prospective clinical study The results of this study will provide a reference for aging nutrition and health care
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None