Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001487
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Treatment of Mid-Life-Related Mood Disorders
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Dehydroepiandrosterone Treatment of Mid-Life-Related Mood Disorders in Women and Men
Status:
COMPLETED
Status Verified Date:
2004-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Dehydroepiandrosterone DHEA is a hormone produced by the adrenal gland As humans grow older the levels of DHEA naturally decrease Low levels of DHEA have been associated with a variety of harmful effects including increased heart disease decreased immune system function decreased bone density osteoporosis high cholesterol and increased fat to muscle ratio
Blood levels of DHEA and its sulfate form DHEA-S begin dropping when humans are in their 20s By the time humans are in their 40s and 50s levels of DHEA and DHEA-S levels are at 50 of their peak Previous studies have shown that levels of these hormones are associated with feelings of well-being and enjoyment of leisure activities
In this study researchers are interested in the effects on mood and behavior of DHEA in men and women with mid-life related mood disorders Specifically researchers would like to find out if increasing levels of DHEA will lessen the symptoms associated with these disorders
Blood levels of DHEA and its sulfate form DHEA-S begin dropping when humans are in their 20s By the time humans are in their 40s and 50s levels of DHEA and DHEA-S levels are at 50 of their peak Previous studies have shown that levels of these hormones are associated with feelings of well-being and enjoyment of leisure activities
In this study researchers are interested in the effects on mood and behavior of DHEA in men and women with mid-life related mood disorders Specifically researchers would like to find out if increasing levels of DHEA will lessen the symptoms associated with these disorders
Detailed Description:
Dehydroepiandrosterone DHEA is a hormone produced by the adrenal gland in concentrations that decrease with age In humans low DHEA levels have been associated with a variety of adverse biological consequences including increased cardiovascular disease decreased immune function decreased bone density negative lipid profile and an increased fat to muscle ratio
In this study we investigate the effects on mood and behavior of DHEA in men and women with midlife-related mood disorders in a double-blind placebo-controlled crossover trial We specifically ask whether increasing DHEA levels will mitigate any or all of the neurasthenia-like symptoms characteristic of these disorders
In this study we investigate the effects on mood and behavior of DHEA in men and women with midlife-related mood disorders in a double-blind placebo-controlled crossover trial We specifically ask whether increasing DHEA levels will mitigate any or all of the neurasthenia-like symptoms characteristic of these disorders
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 95-M-0151 | None | None | None |