Ignite Creation Date:
2024-05-06 @ 7:29 PM
Last Modification Date:
2024-10-26 @ 3:08 PM
Study NCT ID:
NCT06038292
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-02-21
First Post:
2023-09-08
Brief Title:
The Relationship Between Rheumatoid Arthritis and Osteoporosis and Factors Contributing to This Connection
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
The Relationship Between Rheumatoid Arthritis and Osteoporosis and Factors Contributing to This Connection
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to explore the association between RA and osteoporosis and highlight the risk factors that RA patients have that may cause or affect osteoporosis progress
Detailed Description:
Rheumatoid arthritis RA is an autoimmune chronic connective tissue disease that produces persistent systemic inflammation with joint inflammation leading to function loss and joint destruction It can finally lead to some serious systematic disorders such as cardiovascular pulmonary skeletal and psychological disorders
One of the most severe comorbidities of RA is osteoporosis OP which is a chronic metabolic skeletal disease leading to an increased risk of low trauma fracture and many factors can play a role in increasing this association including treating RA patients with glucocorticoid over a long duration chronic joints inflammation calcium malabsorption age of the patients and genetics
Osteoporosis is characterized by microarchitectural deterioration of bone tissue and low bone mass The most commonly used measurement for OP is bone mineral density BMD and DEXA dual x-ray absorptiometry Scans
Osteoporosis can result in devastating physical psychosocial and economic consequences Still it is often overlooked and undertreated in large part because it is clinically silent there are no symptoms before a fracture occurs
Epidemiological studies indicate that about 60-80 of RA patients have a comorbidity of OP
These two kinds of complex diseases may share some common genetic mechanisms and biological processes For example proinflammatory cytokines including TNF-α IL-17 IL-6 and IL-1 have been reported to be closely associated with OP and they also play important roles in the development of RA Also the inflammation in the joints increases bone absorption and makes RA patients susceptible to bone loss and osteoporosis development
One of the primary drugs recommended for the treatment of RA is a corticosteroid glucocorticoid GC Both systemic corticosteroid and intraarticular corticosteroid are proven to be risk factors for developing secondary osteoporosis and osteoporotic fracture The risk increases with the long duration of use and using a high dose Longer duration and severity of RA were also indicated as independent risk factors for vertebral fractures The American College of Rheumatology ACR recommended increasing the awareness of RA patients about BMD and getting DXA done for identifying a patient at risk of osteoporosis
One of the most severe comorbidities of RA is osteoporosis OP which is a chronic metabolic skeletal disease leading to an increased risk of low trauma fracture and many factors can play a role in increasing this association including treating RA patients with glucocorticoid over a long duration chronic joints inflammation calcium malabsorption age of the patients and genetics
Osteoporosis is characterized by microarchitectural deterioration of bone tissue and low bone mass The most commonly used measurement for OP is bone mineral density BMD and DEXA dual x-ray absorptiometry Scans
Osteoporosis can result in devastating physical psychosocial and economic consequences Still it is often overlooked and undertreated in large part because it is clinically silent there are no symptoms before a fracture occurs
Epidemiological studies indicate that about 60-80 of RA patients have a comorbidity of OP
These two kinds of complex diseases may share some common genetic mechanisms and biological processes For example proinflammatory cytokines including TNF-α IL-17 IL-6 and IL-1 have been reported to be closely associated with OP and they also play important roles in the development of RA Also the inflammation in the joints increases bone absorption and makes RA patients susceptible to bone loss and osteoporosis development
One of the primary drugs recommended for the treatment of RA is a corticosteroid glucocorticoid GC Both systemic corticosteroid and intraarticular corticosteroid are proven to be risk factors for developing secondary osteoporosis and osteoporotic fracture The risk increases with the long duration of use and using a high dose Longer duration and severity of RA were also indicated as independent risk factors for vertebral fractures The American College of Rheumatology ACR recommended increasing the awareness of RA patients about BMD and getting DXA done for identifying a patient at risk of osteoporosis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None