Ignite Creation Date:
2024-05-06 @ 7:29 PM
Last Modification Date:
2024-10-26 @ 3:08 PM
Study NCT ID:
NCT06031532
Status:
COMPLETED
Last Update Posted:
2023-09-11
First Post:
2023-09-04
Brief Title:
Effect of Vitamin A and Calcium in Patients With Non-alcoholic Fatty Liver Disease
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Effect of Vitamin A and Calcium in Patients With Non-alcoholic Fatty Liver Disease
Status:
COMPLETED
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Non-alcoholic fatty liver disease NAFLD has become the most common liver disease at a global scale and is strongly associated with the obesity and metabolic syndrome It is recognized as a hepatic manifestation of the metabolic syndrome and characterized by lipid infiltration in the hepatocytes NAFLD comprises a range of diseases from simple steatosis to non-alcoholic steatohepatitis NASH fibrosis cirrhosis and may progress to hepatocellular carcinoma HCC
The worldwide prevalence of NAFLD is estimated to be 24 while it is reported to have much higher incidence in patients with metabolic syndrome and type 2 diabetes T2D 5 The mortality rate and the number of liver transplantations owing to NAFLD and NASH are increasing making it the second leading cause of liver transplant in the United States
Tow significant metabolic abnormalities commonly linked to NAFLD are insulin resistance IR and increased supply of fatty acids to the liver Chronic liver diseases CLD including NAFLD are commonly associated with nutrient and vitamins deficiencies such as those of vitamins D and A 89
Almost all studies documenting vitamin A status in metabolic syndrome MetS report reductions in serum retinol retinoic acid andor β-carotene that are inversely correlated with MetS features including obesity insulin resistance glucose intolerance and hypertriglyceridemia In line with these observations inadequate serum retinol levels 105 μmolL were found in 11-36 of morbidly obese adults with ultrasonography-proven NAFLD and a significant association between low retinol levels and insulin resistance IR was found Moreover serum retinol levels were inversely associated with body mass and serum transaminases in patients with NAFLD suggesting a link between retinol inadequacy and development of disease
The liver plays a critical role in lipid metabolism by taking up serum free fatty acids FFA that are involved in the synthesis storage and transport of lipid metabolites The accumulation of excess triacylglycerol TG within the liver due to the entry of excess FFA from the obese adipose tissue due to increased lipolysis leads to the development of non-alcoholic fatty liver diseases NAFLD
The worldwide prevalence of NAFLD is estimated to be 24 while it is reported to have much higher incidence in patients with metabolic syndrome and type 2 diabetes T2D 5 The mortality rate and the number of liver transplantations owing to NAFLD and NASH are increasing making it the second leading cause of liver transplant in the United States
Tow significant metabolic abnormalities commonly linked to NAFLD are insulin resistance IR and increased supply of fatty acids to the liver Chronic liver diseases CLD including NAFLD are commonly associated with nutrient and vitamins deficiencies such as those of vitamins D and A 89
Almost all studies documenting vitamin A status in metabolic syndrome MetS report reductions in serum retinol retinoic acid andor β-carotene that are inversely correlated with MetS features including obesity insulin resistance glucose intolerance and hypertriglyceridemia In line with these observations inadequate serum retinol levels 105 μmolL were found in 11-36 of morbidly obese adults with ultrasonography-proven NAFLD and a significant association between low retinol levels and insulin resistance IR was found Moreover serum retinol levels were inversely associated with body mass and serum transaminases in patients with NAFLD suggesting a link between retinol inadequacy and development of disease
The liver plays a critical role in lipid metabolism by taking up serum free fatty acids FFA that are involved in the synthesis storage and transport of lipid metabolites The accumulation of excess triacylglycerol TG within the liver due to the entry of excess FFA from the obese adipose tissue due to increased lipolysis leads to the development of non-alcoholic fatty liver diseases NAFLD
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None