Ignite Creation Date:
2024-05-06 @ 7:28 PM
Last Modification Date:
2024-10-26 @ 3:07 PM
Study NCT ID:
NCT06024889
Status:
COMPLETED
Last Update Posted:
2024-02-16
First Post:
2023-08-23
Brief Title:
Acute Effects of Furosemide on Hemodynamics and Pulmonary Congestion in Acute Decompensated Heart Failure
Sponsor:
Johannes Grand
Organization:
Copenhagen University Hospital Hvidovre
Study Overview
Official Title:
Acute Effects of Furosemide on Hemodynamics and Pulmonary Congestion in Acute Decompensated Heart Failure
Status:
COMPLETED
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Intravenous IV loop diuretics have been a key component in treating pulmonary edema since the 1960s and has a Class 1 recommendation in the 2021 guidelines for acute heart failure However no randomized clinical trials have investigated loop diuretics versus other interventions for acute heart failure and clinical knowledge of the hemodynamic effects of furosemide is based in studies from the 1970s In this study we aim to assess the acute effect of furosemide on cardiac filling pressures and pulmonary congestion
Hypothesis
Administration of furosemide induces a hyperacute within 30 minutes lowering of cardiac filling pressures and pulmonary congestion before significant diuresis occurs
Design
A prospective interventional study including 20 patients admitted due to a clinical diagnosis of acute heart failure with pulmonary congestion
Intervention
80 mg of furosemide is administered IV Measurements include blood pressure peripheral oxygen saturation pulmonary fluid content by ReDS ultrasound examination of heart and lungs and assessment of cardiac filling pressures with doppler and strain analysis Measurements are repeated at several time points until 6 hours have passed
Hypothesis
Administration of furosemide induces a hyperacute within 30 minutes lowering of cardiac filling pressures and pulmonary congestion before significant diuresis occurs
Design
A prospective interventional study including 20 patients admitted due to a clinical diagnosis of acute heart failure with pulmonary congestion
Intervention
80 mg of furosemide is administered IV Measurements include blood pressure peripheral oxygen saturation pulmonary fluid content by ReDS ultrasound examination of heart and lungs and assessment of cardiac filling pressures with doppler and strain analysis Measurements are repeated at several time points until 6 hours have passed
Detailed Description:
Prospective observational study of the acute and subacute effects of furosemide in patients with acute heart failure
After inclusion 80 mg of furosemide is administered IV
Measurements include blood pressure peripheral oxygen saturation pulmonary fluid content ultrasound examination of heart and lungs and assessment of cardiac filling pressures with doppler and strain analysis Measurements are repeated at several time points until 6 hours have passed
After inclusion 80 mg of furosemide is administered IV
Measurements include blood pressure peripheral oxygen saturation pulmonary fluid content ultrasound examination of heart and lungs and assessment of cardiac filling pressures with doppler and strain analysis Measurements are repeated at several time points until 6 hours have passed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None