Ignite Creation Date:
2024-05-06 @ 7:27 PM
Last Modification Date:
2024-10-26 @ 3:07 PM
Study NCT ID:
NCT06017635
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-08-30
First Post:
2023-08-01
Brief Title:
Non-invasive Monitoring and Serum Marker Study in Children With Cerebral Edema
Sponsor:
Qilu Hospital of Shandong University
Organization:
Qilu Hospital of Shandong University
Study Overview
Official Title:
Non-invasive Monitoring and Serum Marker Study in Children With Cerebral Edema
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Purpose of the studyThis study aimed to evaluate the clinical significance of serum SUR1 TRPM4 and MMP-9 in the diagnosis of cerebral edema in children with cerebral edema admitted to PICU by comparing them with CT results and perturbation coefficients so as to provide biological indicators for clinical diagnosis of cerebral edema and provide targets for the treatment of cerebral edema in various diseases
Detailed Description:
Early and efficient use of various measures to control and monitor peripheral cerebral edema and intracranial pressure timely and accurate adjustment of treatment plan to reduce the degree of cerebral edema and reduce intracranial pressure can significantly improve the development of the disease and prognosis recovery At present the clinical diagnosis of cerebral edema is mainly through clinical manifestations and imaging examinations and there is a lack of corresponding biological examination methodsPurpose of the study1By analyzing the correlation between serum SUR1 TRPM4 MMP-9 and the electromagnetic disturbance coefficient cranial CT results Glasgow coma score S100-β NSE and prognostic score at 3 months of discharge the clinical value of serum SUR1 TRPM4 MMP-9 and perturbation coefficient in the diagnosis intracranial pressure monitoring condition assessment and prognosis judgment of cerebral edema in children was explored2By analyzing the changes of the above indicators in various children with cerebral edema admitted to PICU the types of cerebral edema and the cellular and molecular mechanisms of cerebral edema caused by different diseases were explored
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None