Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001604
Status:
COMPLETED
Last Update Posted:
2024-07-15
First Post:
1999-11-03
Brief Title:
Genetic Linkage Studies of Stuttering
Sponsor:
National Institute on Deafness and Other Communication Disorders NIDCD
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Genetic Studies of Stuttering
Status:
COMPLETED
Status Verified Date:
2023-12-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Stuttering is an abnormality in speech that affects the rhythm of speech People who stutter know what they wish to say but at the time are unable to say it because of involuntary repetition unnecessary lengthening prolongation or early stopping cessation Stuttering is characterized by repetitions or prolongation of the first syllable or silent prolongations sometimes known as blocks
Researcher intend on studying the genetic basis for stuttering The goal of the study is to find the genes that help cause stuttering and determine regions of the human genetic make-up genome that are linked to stuttering To do this researchers will study the patterns of inheritance in families who have had members who stutter
The study has two objectives
The first objective is to develop a large collection of DNA samples from individuals in stuttering families that will include both members that stutter and who do not stutter
The second objective of the study will be to find out the basic combination of genes genotype making up all of the participants DNA Once this is completed researchers hope to map out and find areas or regions of DNA that are linked to stuttering
Genetic linkage is the initial step in positional cloning and the cloning of genes which predispose individuals to stuttering is a long term goal of this research studyTAB
Researcher intend on studying the genetic basis for stuttering The goal of the study is to find the genes that help cause stuttering and determine regions of the human genetic make-up genome that are linked to stuttering To do this researchers will study the patterns of inheritance in families who have had members who stutter
The study has two objectives
The first objective is to develop a large collection of DNA samples from individuals in stuttering families that will include both members that stutter and who do not stutter
The second objective of the study will be to find out the basic combination of genes genotype making up all of the participants DNA Once this is completed researchers hope to map out and find areas or regions of DNA that are linked to stuttering
Genetic linkage is the initial step in positional cloning and the cloning of genes which predispose individuals to stuttering is a long term goal of this research studyTAB
Detailed Description:
A primary goal of this study is to ascertain regions of the human genome which show genetic linkage to stuttering Genetic linkage will be determined by first obtaining genomic DNA from both affected and unaffected adults and children from families containing pairs of individuals who stutter as adults Individuals who stutter from genetically isolated populations will also be sampled Phenotype will be assigned by a speech-language pathologist and DNA samples will be obtained from affected and unaffected family members from 2 cc of saliva or from 20 cc of blood These DNA samples will then be genotyped using markers distributed across the human genome The genotypic information analyzed to determine which markers or variants show linkage to stuttering The initial goal of this study is to identify specific genetic variants which predispose individuals to stuttering No genetic information will be provided back to participants A secondary goal of the study will be to perform broad clinical evaluations of the individuals found to have mutations that cause stuttering These will take place at the NIH Clinical Center and will include standard procedures including history and physical neurological exam audiological exam ophthalmologic exam electromyographic EMG exam electroencephalography EEG X-rays speech evaluation and brain imaging including MRI and fMRI
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 97-DC-0057 | None | None | None |