Ignite Creation Date:
2024-05-06 @ 7:27 PM
Last Modification Date:
2024-10-26 @ 3:07 PM
Study NCT ID:
NCT06015815
Status:
COMPLETED
Last Update Posted:
2023-08-29
First Post:
2023-08-17
Brief Title:
The Association of MicroRNA21-155 Levels With Acute Side Effects In Patients With Stage III NSCLC With Definitive CRT
Sponsor:
Ankara University
Organization:
Ankara University
Study Overview
Official Title:
The Association of MicroRNA-21 And MicroRNA-155 Levels With Acute Side Effects In Patients With Stage III Non Small Lung Cancer With Definite Chemoradiotherapy
Status:
COMPLETED
Status Verified Date:
2023-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The present investigation constitutes a prospective cohort study The objectives encompass the assessment of miRNA expression levels in total exosomes derived from peripheral circulation tissues of stage III definite KRT NSCLC patients both at the beginning and conclusion of their treatment Furthermore an exploration is conducted into the potential correlation existing between alterations in miRNA levels and the incidence of acute treatment-related side effects
Detailed Description:
Categorical variables were illustrated using both percentage distributions and numerical counts while continuous variables were characterized using the mean accompanied by the standard deviation and the median accompanied by the minimum and maximum values The assessment of the normality of continuous variables encompassed a combination of visual methods such as histograms and probability plots along with analytical tests like the Kolmogorov-Smirnov and Shapiro-Wilk tests
In instances where data exhibited a normal distribution Students t-test was utilized for comparing two groups For non-normally distributed data the Mann-Whitney U test was applied The comparison of categorical variables between independent groups involved Chi-square and Fishers exact tests Changes within dependent groups were evaluated using the Wilcoxon test When performing pairwise comparisons among three or more groups p-values were calculated while employing Bonferroni correction
For the statistical analysis of the research data the Statistical Package for Social Sciences SPSS version 250 for Windows SPSS Inc Chicago USA was utilized The significance level was set at p005 Additionally it is important to note that p-values falling within the range of 01 to 005 were considered indicative of a statistical trend in this study
In instances where data exhibited a normal distribution Students t-test was utilized for comparing two groups For non-normally distributed data the Mann-Whitney U test was applied The comparison of categorical variables between independent groups involved Chi-square and Fishers exact tests Changes within dependent groups were evaluated using the Wilcoxon test When performing pairwise comparisons among three or more groups p-values were calculated while employing Bonferroni correction
For the statistical analysis of the research data the Statistical Package for Social Sciences SPSS version 250 for Windows SPSS Inc Chicago USA was utilized The significance level was set at p005 Additionally it is important to note that p-values falling within the range of 01 to 005 were considered indicative of a statistical trend in this study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None