Ignite Creation Date:
2024-05-06 @ 7:26 PM
Last Modification Date:
2024-10-26 @ 3:07 PM
Study NCT ID:
NCT06017011
Status:
RECRUITING
Last Update Posted:
2023-12-13
First Post:
2023-03-19
Brief Title:
Clinico-Radiological Characterisation for Remission of Acute Charcot-Neuroarthropathy of Foot
Sponsor:
Post Graduate Institute of Medical Education and Research Chandigarh
Organization:
PGIMER
Study Overview
Official Title:
Clinico-Radiological Characterisation for Remission of Acute Charcot-Neuroarthropathy of Foot
Status:
RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Charcots neuro-arthropathy is a condition which is generally prevalent among the diabetic patients Acute charcots neuro-arthropathy is characterized by signs of inflammation hot red swelling around the involved joint along with a temperature difference of greater than 2 degree centigrade between the two feet This is often misdiagnosed as cellulitis sprains or deep vein thrombosis The diagnosis of this condition is mainly made clinically and aided by x-ray of foot MRI of foot and sometimes by bone scan The therapy that is accepted unanimously is putting on a total contact cast The duration of this therapy depends on the regular temperature monitoring of both the feet When the temperature difference between the two feet comes down to less than 2 degree centigrade then it is defined as clinical remission and the offloading of the foot is stopped There are other modalities that have been tried for the treatment of acute charcots neuro-arthropathy with medications like methyl prednisolone bisphosphonates and the effects of medical management of acute charcots neuro-arthropathy was a mixed one with no definite recommendation regarding use of medical management in this condition If the patients are denied these treatment then there is progression of the disease process and can lead to the development of chronic changes in the form of fractures dislocation gangrene foot ulcers and ultimately amputation The end point of the treatment with total contact cast is taken as the decrease in the temperature difference of less than 2 degree centigrade between the two feet This point is regarded as the point of clinical remission in cases of acute charcots neuro-arthropathy But there has been instances where there have been 12-33 of recurrences when this clinical remission has been used as a criteria for discontinuation of offloading With time there has been evolution in the imaging of charcots neuro-arthropathy There has been advent of MRI and MRS of the foot for monitoring of acute charcots neuro-arthropathy remission which is the most sensitive technique for the recognition of early bony changes in charcot neuro-arthropathy PET scan has also been used including bone scan and FDG PET scan for the evaluation of acute charcots neuro-arthropathy remission Even with these modalities the actual remission criteria that would decrease the complication of early offloading as done at the time of clinical remission is still missing So here the investigators aim to monitor the process of remission of acute charcot-neuroarthropathy of foot both clinically as well as radiologically with the help of MRI of the foot with diffusion weighted and apparent diffusion coefficient imaging along with a novel PET scan for charcots neuroarthropathy that is F18-Fluoride PET scan which will given a quantitative estimation of the process of remission of acute charcot-neuroarthropathy in the form of SUV max Thus this quantitative value can help to assess the trends of remission in acute charcot neuroarthropathy of foot
Detailed Description:
Charcots neuro-arthropathy is a condition which is generally prevalent among the diabetic patient It is a condition which primarily affects the bones and the joints The presentation of charcots neuro-arthropathy can be an acute or a chronic type depending upon the temperature difference between the two feet ie greater than 2 degree centigrade Acute charcots neuro-arthropathy presents with signs of redness swelling and raised temperature of the involved area The condition if not detected in the acute condition leads to chronic changes in the joints which leads to joint dislocation fractures and development of rocker-bottom foot and also can lead to a state where amputation of the affected foot is needed Acute charcots neuro-arthropathy is characterized by signs of inflammation hot red swelling around the involved joint This is often misdiagnosed as cellulitis sprains or deep vein thrombosis The diagnosis of this condition is mainly made clinically and aided by x-ray of foot MRI of foot and sometimes by bone scan The therapy that is accepted unanimously is putting on a total contact cast The duration of this therapy depends on the regular temperature monitoring of both the feet When the temperature difference between the two feet comes down to less than 2 degree centigrade then it is defined as clinical remission and the offloading of the foot is stopped Keeping in mind the effects of RANKL in the pathogenesis of acute Charcot neuro-arthropathy Zoledronic acid was used as a treatment modality for acute charcot neuro-arthropathy But it showed that it was inferior to the application of total contact cast There have been trials were methylprednisolone combined with total contact cast have been used for treatment and the outcome has been compared with the use of zoledronate in patients on total contact cast It had shown that zoledronate with total contact cast had an improvement of bone mineral density and on the other hand there was a decrease with steroids Overall the effects of medical management of acute charcots neuro-arthropathy was a mixed one with no definite recommendation regarding use of medical management in this condition So total contact cast is the gold standard for the management of acute charcots neuro-arthropathy It has led to the healing of ulcers to the range of 75 in cases of acute charcots neuro-arthropathy If the patients are denied these treatment then there is progression of the disease process and can lead to the development of chronic changes in the form of fractures dislocation gangrene foot ulcers and ultimately amputation
The end point of the treatment with total contact cast is taken as the decrease in the temperature difference of less than 2 degree centigrade between the two feet This point is regarded as the point of clinical remission in cases of acute charcots neuro-arthropathy But there has been instances where there have been 12-33 of recurrences when this clinical remission has been used as a criteria for discontinuation of offloading
There has been advent of MRI and MRS of the foot for monitoring of acute charcots neuro-arthropathy remission which is the most sensitive technique for the recognition of early bony changes in charcot neuro-arthropathy PET scan has also been used including bone scan and FDG PET scan for the evaluation of acute charcots neuro-arthropathy remission These modalities have been evaluated to test the actual remission of acute charcots neuro-arthropathy Even with these modalities the actual remission criteria that would decrease the complication of early offloading as done at the time of clinical remission is still missing
There is no quantitative method available to monitor the process of remission of acute charcot-neuroarthropathy and accurately label the remission
The pathophysiology of acute charcot neuro-arthropathy has two main postulates One is the neurovascular theory in which it is thought to have nerve damage and it leads to increased local vascularity which leads to activation of increased osteoclastic activity with development of secondary osteopenia fractures and deformity The other theory is the more accepted one and has attracted a lot of recent research around it This involves the neuro-traumatic theory where due to the presence of neuropathy in these diabetic patients they are not able to realize the microtrauma that they sustain This leads to the development of a state of inflammation resulting in the raised levels of raised IL6 and TNFalpha There is also activation of the RANKL and OPG pathways leading to bone destruction This highlights the importance of RANKL in the pathogenesis of acute charcot neuro-arthropathy
Earlier bone scan MR Spectroscopy FDG PET scan has been used to evaluate quantitatively the process of remission of acute charcot-neuroarthropathy Here we try to quantitate the process of remission of acute charcot neuroarthropathy by using F18- Fluoride PET scan of the foot along with MRI of the foot with Diffusion weighted and apparent diffusion coefficient imaging sequences
F18- Fluoride PET scan is a modality that is highly sensitive for bone related pathology It gets attached to area where there is increased osteoblastic activity The mechanism of skeletal uptake of 18F-NaF is based on ion exchange which is similar to that of 99mTc-MDP Bone has a strong architecture and it is due to a crystalline matrix of calcium and phosphate known as hydroxyapatite which is composed of many different positive and negative ions 18F ions is exchanged with hydroxyl ions OH- on the surface of the hydroxyapatite to form fluoroapatite The sensitivity of F18 Fluoride PET Scan is also higher than the F18 FDG PET scan as well as bone scan for bone related pathologies Pathologically altered osteoblastic activity is most efficiently taken up by 18F-NaF-PET which detects incident photons that results from positron emission of radioactive fluoride ions that have become incorporated into the hydroxyapatite surface of newly formed bone
It has still not been used in monitoring of remission of acute charcot neuro-arthropathy but as this gives a quantitative value in the form of SUV so it can be used in the monitoring of acute charcot neuro-arthropathy remission
MRI of the Foot with Diffusion Weighted Imaging DWI sequence in the MRI is used to see if there is any restriction of the brownian motion It helps to detect conditions where there is restriction of the brownian motion like infection DWI sequence also has an advantage in that it helps to differentiate osteomyelitis from acute charcot-neuro-arthropathy Apparent Diffusion Coefficient ADC sequence can give a semi-quantitative value by plotting the graph from the obtained imaging of the foot and thus it may help in the monitoring of remission
It has been postulated that RANKL plays a very pivotal role in the process of development of acute charcot neuro-arthropathy The increased levels of RANKL leads to the activation of the osteoclastic activity and there is extensive destruction of the joints seen RANKL has been used for studying the process of remission in acute charcot neuro-arthropathy It has been studied that during the follow up of two years in the patients of acute charcot neuro-arthropathy after the application of total contact cast there was significant decrease in the levels and it had come down to comparable values with the healthy controls
Osteoprotegerin is another biomarker that has attracted attention for research This is generally involved in the inhibition of osteoclastic activity So in areas where there is increase in the osteoclastic activity and elevation of the RANKL there is also similar elevation of the OPG levels as well as the osteoclastic and the osteoblastic activities which go hand in hand
So here the investigators want to use these quantitative imaging tools and biochemical markers to assess the trends of remission in acute charcot neuroarthropathy and compare it with clinical remission
The end point of the treatment with total contact cast is taken as the decrease in the temperature difference of less than 2 degree centigrade between the two feet This point is regarded as the point of clinical remission in cases of acute charcots neuro-arthropathy But there has been instances where there have been 12-33 of recurrences when this clinical remission has been used as a criteria for discontinuation of offloading
There has been advent of MRI and MRS of the foot for monitoring of acute charcots neuro-arthropathy remission which is the most sensitive technique for the recognition of early bony changes in charcot neuro-arthropathy PET scan has also been used including bone scan and FDG PET scan for the evaluation of acute charcots neuro-arthropathy remission These modalities have been evaluated to test the actual remission of acute charcots neuro-arthropathy Even with these modalities the actual remission criteria that would decrease the complication of early offloading as done at the time of clinical remission is still missing
There is no quantitative method available to monitor the process of remission of acute charcot-neuroarthropathy and accurately label the remission
The pathophysiology of acute charcot neuro-arthropathy has two main postulates One is the neurovascular theory in which it is thought to have nerve damage and it leads to increased local vascularity which leads to activation of increased osteoclastic activity with development of secondary osteopenia fractures and deformity The other theory is the more accepted one and has attracted a lot of recent research around it This involves the neuro-traumatic theory where due to the presence of neuropathy in these diabetic patients they are not able to realize the microtrauma that they sustain This leads to the development of a state of inflammation resulting in the raised levels of raised IL6 and TNFalpha There is also activation of the RANKL and OPG pathways leading to bone destruction This highlights the importance of RANKL in the pathogenesis of acute charcot neuro-arthropathy
Earlier bone scan MR Spectroscopy FDG PET scan has been used to evaluate quantitatively the process of remission of acute charcot-neuroarthropathy Here we try to quantitate the process of remission of acute charcot neuroarthropathy by using F18- Fluoride PET scan of the foot along with MRI of the foot with Diffusion weighted and apparent diffusion coefficient imaging sequences
F18- Fluoride PET scan is a modality that is highly sensitive for bone related pathology It gets attached to area where there is increased osteoblastic activity The mechanism of skeletal uptake of 18F-NaF is based on ion exchange which is similar to that of 99mTc-MDP Bone has a strong architecture and it is due to a crystalline matrix of calcium and phosphate known as hydroxyapatite which is composed of many different positive and negative ions 18F ions is exchanged with hydroxyl ions OH- on the surface of the hydroxyapatite to form fluoroapatite The sensitivity of F18 Fluoride PET Scan is also higher than the F18 FDG PET scan as well as bone scan for bone related pathologies Pathologically altered osteoblastic activity is most efficiently taken up by 18F-NaF-PET which detects incident photons that results from positron emission of radioactive fluoride ions that have become incorporated into the hydroxyapatite surface of newly formed bone
It has still not been used in monitoring of remission of acute charcot neuro-arthropathy but as this gives a quantitative value in the form of SUV so it can be used in the monitoring of acute charcot neuro-arthropathy remission
MRI of the Foot with Diffusion Weighted Imaging DWI sequence in the MRI is used to see if there is any restriction of the brownian motion It helps to detect conditions where there is restriction of the brownian motion like infection DWI sequence also has an advantage in that it helps to differentiate osteomyelitis from acute charcot-neuro-arthropathy Apparent Diffusion Coefficient ADC sequence can give a semi-quantitative value by plotting the graph from the obtained imaging of the foot and thus it may help in the monitoring of remission
It has been postulated that RANKL plays a very pivotal role in the process of development of acute charcot neuro-arthropathy The increased levels of RANKL leads to the activation of the osteoclastic activity and there is extensive destruction of the joints seen RANKL has been used for studying the process of remission in acute charcot neuro-arthropathy It has been studied that during the follow up of two years in the patients of acute charcot neuro-arthropathy after the application of total contact cast there was significant decrease in the levels and it had come down to comparable values with the healthy controls
Osteoprotegerin is another biomarker that has attracted attention for research This is generally involved in the inhibition of osteoclastic activity So in areas where there is increase in the osteoclastic activity and elevation of the RANKL there is also similar elevation of the OPG levels as well as the osteoclastic and the osteoblastic activities which go hand in hand
So here the investigators want to use these quantitative imaging tools and biochemical markers to assess the trends of remission in acute charcot neuroarthropathy and compare it with clinical remission
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None