Ignite Creation Date:
2024-05-06 @ 7:26 PM
Last Modification Date:
2024-10-26 @ 3:07 PM
Study NCT ID:
NCT06015763
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-08-29
First Post:
2023-08-23
Brief Title:
Correlation Between HPylori Colonization and Gastritis
Sponsor:
Merna Mawgoud Zaki Bechit
Organization:
Assiut University
Study Overview
Official Title:
Correlation Between HPylori Colonization and Severity of Gastritis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To study the prevelance rate of Hpylori colonization in patients with gastritis
To correlate the Hpylori colonization with endoscopic finding To correlate both Hpylori colonization and endoscopic finding with clinical manifestation
To correlate the Hpylori colonization with endoscopic finding To correlate both Hpylori colonization and endoscopic finding with clinical manifestation
Detailed Description:
Helicobacter pylori is a gram negative microaerophilic spiral bacterium that is usually found in the stomach and thereby cause infection which is associated with varying degrees of damage of superficial and glandular epithelium
Chronic gastritis is a histological entity that is defined by an inflammatory infiltrate of lymphoblasma cells cocsometimes polynuclear neutrophils and by progressive glandular atrophy of the gastric mucosaand probably the main cause of chronic inflammation in the gastric mucosa which is usually caused by Hpylori infection
In addition to chronic gastritis almost all benign gastroduodenal diseases including peptic ulcer mucosa associated lymphoid tissue lymphoma and malignant gastroduodenal adenocarcinoma occurs due to previous Hpylori infection that is usually started with gastric precancerous lesion gastric atrophy gastric intestinal metaplasia dysplasia and then turned to gastric carcinoma
So the evaluation of Hpylori infection status yo non-infection past infection current infection by endoscopy has therefore become increasingly important
The Sydney grading system is one of the most important recognised tools yo charactize histological lesions of chronic gastritis
The system categorise gastritis according to intensity of mononuclear inflammatory cellular infiltrate polymorph activity atrophy intestinal metaplasia and Hpylori density into mild moderate and severe categories but up till now there is non-standard histology reporting formats are still widely used for gastritis and even specialists are often frustrated by the histological definition that make it difficult to identify candidates for clinico-endoscopic surveillance
Therefore the eradication of this bacterium aimed to interrupt the carcinogenesis process and prevent recurrence of gastritis and peptic ulcer disease
However despite of the significant researches conducted on Hpylori colonization in gastric mucosa and its association with endoscopic finding and severity of clinical manifestations and its impact on the Egyptian population is still a topic of debate
Currently there is no study has definitively determined this relationship in the Egyptian population despite the high prevalence rate of Hpylori infection
Chronic gastritis is a histological entity that is defined by an inflammatory infiltrate of lymphoblasma cells cocsometimes polynuclear neutrophils and by progressive glandular atrophy of the gastric mucosaand probably the main cause of chronic inflammation in the gastric mucosa which is usually caused by Hpylori infection
In addition to chronic gastritis almost all benign gastroduodenal diseases including peptic ulcer mucosa associated lymphoid tissue lymphoma and malignant gastroduodenal adenocarcinoma occurs due to previous Hpylori infection that is usually started with gastric precancerous lesion gastric atrophy gastric intestinal metaplasia dysplasia and then turned to gastric carcinoma
So the evaluation of Hpylori infection status yo non-infection past infection current infection by endoscopy has therefore become increasingly important
The Sydney grading system is one of the most important recognised tools yo charactize histological lesions of chronic gastritis
The system categorise gastritis according to intensity of mononuclear inflammatory cellular infiltrate polymorph activity atrophy intestinal metaplasia and Hpylori density into mild moderate and severe categories but up till now there is non-standard histology reporting formats are still widely used for gastritis and even specialists are often frustrated by the histological definition that make it difficult to identify candidates for clinico-endoscopic surveillance
Therefore the eradication of this bacterium aimed to interrupt the carcinogenesis process and prevent recurrence of gastritis and peptic ulcer disease
However despite of the significant researches conducted on Hpylori colonization in gastric mucosa and its association with endoscopic finding and severity of clinical manifestations and its impact on the Egyptian population is still a topic of debate
Currently there is no study has definitively determined this relationship in the Egyptian population despite the high prevalence rate of Hpylori infection
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None