Ignite Creation Date:
2024-05-06 @ 7:26 PM
Last Modification Date:
2024-10-26 @ 3:06 PM
Study NCT ID:
NCT06003270
Status:
RECRUITING
Last Update Posted:
2024-04-08
First Post:
2023-08-15
Brief Title:
Biological Effects of Quercetin in COPD Phase II
Sponsor:
Temple University
Organization:
Temple University
Study Overview
Official Title:
Effects of Quercetin on the Oxidative Stress and Inflammatory Markers in COPD Phase II
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
polyphenols
Brief Summary:
This study determines whether quercetin supplementation reduces the inflammation and oxidative stress markers in patients with chronic obstructive pulmonary disease It is small study with 8 subjects receiving quercetin 1000 mgday 8 patients receiving 500 mgday and 4 subjects receive placebo
Detailed Description:
Chronic obstructive pulmonary disease COPD is a progressive lung disorder and affects millions of people globally Although the exact mechanisms of pathogenesis of this disease are not well-understood the general consensus is that oxidative stress and inflammation induced by exposure to cigarette smoke or other environmental or occupational hazards are responsible for development of COPD Therefore therapies aimed at decreasing oxidative stress and inflammation constitutes an important component of treating COPD
The current pharmacological therapies may provide temporary symptom relief reduce acute exacerbations and hospitalizations but are associated with side effects Therefore complementary method of treatment with potentially fewer side effects and relatively well-tolerated provide promising alternative One such compound is quercetin which is plant polyphenol and is present in variety of foods that we consume Quercetin has potent antioxidant and anti-inflammatory properties and reduces oxidative stress and inflammation in a preclinical model of COPD Quercetin exerts it antioxidant properties not only by neutralizing free radical species but also by enhancing the expression of antioxidant enzymes Similarly quercetin inhibits various protein and lipid kinases by competing for adenosine triphosphate ATP binding sites thus reducing the inflammatory pathways
The current pharmacological therapies may provide temporary symptom relief reduce acute exacerbations and hospitalizations but are associated with side effects Therefore complementary method of treatment with potentially fewer side effects and relatively well-tolerated provide promising alternative One such compound is quercetin which is plant polyphenol and is present in variety of foods that we consume Quercetin has potent antioxidant and anti-inflammatory properties and reduces oxidative stress and inflammation in a preclinical model of COPD Quercetin exerts it antioxidant properties not only by neutralizing free radical species but also by enhancing the expression of antioxidant enzymes Similarly quercetin inhibits various protein and lipid kinases by competing for adenosine triphosphate ATP binding sites thus reducing the inflammatory pathways
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R33AT009991 | NIH | None | httpsreporternihgovquickSearchR33AT009991 |