Ignite Creation Date:
2024-05-06 @ 7:25 PM
Last Modification Date:
2024-10-26 @ 3:06 PM
Study NCT ID:
NCT06000358
Status:
RECRUITING
Last Update Posted:
2023-08-21
First Post:
2023-08-03
Brief Title:
The Effect of Combined Cryotherapy and Immunotherapy on Systemic T Cell Changes and Clinical Outcomes in Metastatic Non-small Cell Lung Cancer
Sponsor:
Lithuanian University of Health Sciences
Organization:
Lithuanian University of Health Sciences
Study Overview
Official Title:
The Effect of Combined Cryotherapy and Immunotherapy on Systemic T Cell Changes and Clinical Outcomes in Metastatic Non-small Cell Lung Cancer
Status:
RECRUITING
Status Verified Date:
2023-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
LUCACRIMUNO
Brief Summary:
Lung cancer remains one of the most commonly diagnosed oncological diseases worldwide and the first in terms of mortality Although immune checkpoint inhibitors form the backbone of current metastatic non-small cell lung cancer treatments there is still no ideal predictive marker for its efficacy and patients still achieve suboptimal results in overall response and survival While immune checkpoint inhibitors are known to shift systemic anti-tumor immune response from suppression to stimulation in some patients the investigators hypothesize that this effect can be further enhanced by cryotherapy especially in cold tumors If proven successful cryotherapy in combination with immunotherapy could potentiate a more powerful immune response compared to systemic therapy alone improve overall response rate patients survival without disease progression and overall survival The investigators therefore aim to use combined local tumor cryotherapy combined with immune checkpoint inhibitor therapy to induce and evaluate systemic anti-tumor T lymphocyte response and achieve improved non-small cell lung cancer patient outcomes than with immunotherapy alone
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None