Viewing Study NCT00552357



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Last Modification Date: 2024-10-26 @ 9:37 AM
Study NCT ID: NCT00552357
Status: RECRUITING
Last Update Posted: 2024-07-10
First Post: 2007-10-31

Brief Title: Risk Factors That Increase the Chance of Developing Primary Graft Dysfunction After Lung Transplantation
Sponsor: University of Pennsylvania
Organization: University of Pennsylvania

Study Overview

Official Title: Clinical Risk Factors for Primary Graft Dysfunction
Status: RECRUITING
Status Verified Date: 2024-07
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: Primary graft dysfunction PGD is a severe lung complication that can occur in the days after lung transplant surgery This study will analyze blood samples to determine if high levels of certain chemicals may increase the risk of developing PGD after a lung transplant
Detailed Description: PGD is a severe complication that affects up to 25 of lung transplant patients following surgery Pulmonary edema which is an abnormal build-up of fluid in the lungs and hypoxemia which is low blood oxygen levels are two common symptoms that individuals with PGD experience Treatment for PGD is often expensive and it is the leading cause of death following lung transplantation Many potential lung donors and recipients are considered unsuitable for lung transplantation because of concern for the development of PGD Increased levels of chemicals that are involved in bleeding and clotting including protein C and certain markers of oxidant stress which can cause damage to the bodys cells and tissues may increase a persons risk of developing complications following a lung transplant The purpose of this study is to analyze blood samples to determine if elevated levels of certain chemicals may be associated with an increased risk of developing PGD after lung transplantation

This study will enroll individuals who are undergoing lung or heart and lung transplantation Blood samples will be collected from participants prior to surgery immediately following surgery and 24 hours after surgery Study researchers will also review participants medical records There will be no additional study visits

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: None
Is a FDA Regulated Device?: None
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None
Secondary IDs
Secondary ID Type Domain Link
R01HL087115-01A1 NIH None httpsreporternihgovquickSearchR01HL087115-01A1