Ignite Creation Date:
2024-05-06 @ 7:25 PM
Last Modification Date:
2024-10-26 @ 3:06 PM
Study NCT ID:
NCT06000475
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-02-23
First Post:
2023-08-11
Brief Title:
Enhancing Memory in CPT for PTSD
Sponsor:
VA Office of Research and Development
Organization:
VA Office of Research and Development
Study Overview
Official Title:
Enhancing Memory in Cognitive Processing Therapy for Older Adults With PTSD
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Several psychotherapies for posttraumatic stress disorder PTSD have a strong evidence base for their efficacy but nonresponse rates are high particularly among older Veterans Accumulating evidence indicates that memory deficits and poor learning of therapy contents adversely affect psychotherapy treatment response in PTSD However limited research has examined methods for increasing learning of therapy contents in psychotherapy for PTSD The proposed study aims to examine the feasibility of integrating an intervention to increase learning and memory of psychotherapy content into the provision of a widely used psychotherapy cognitive processing therapy CPT for older adults with PTSD The ultimate goal of this line of research is to develop novel rehabilitation interventions to increase functioning for individuals with PTSD
Detailed Description:
Posttraumatic stress disorder PTSD is prevalent among Veterans and is a substantial public health burden Several psychotherapies including cognitive processing therapy CPT have a strong evidence base for their efficacy in PTSD However many individuals show limited benefit from such treatments particularly older Veterans One factor likely affecting treatment response is poor encoding storage and retrieval of the skills and treatment points that are learned in psychotherapy Individuals with PTSD display deficits in learning and memory and aging is independently associated with declines in memory and executive functioning Thus older adults with PTSD may be at heightened risk of cognitive dysfunction that could impact their ability to benefit from frontline PTSD treatments To this end pre-treatment memory functioning has been shown to consistently predict treatment response in psychotherapy for PTSD Inefficient learning and memory for psychotherapy content may be one mechanism explaining this relationship as poor learning of therapy content is linked with worse treatment adherence and outcomes The primary aim of this proposal is to examine the feasibility and acceptability of integrating a novel Memory Support intervention into the provision of CPT for older adults with PTSD The Memory Support intervention was developed such that specific strategies to enhance encoding and retrieval of therapy content and skills can be integrated into manualized psychotherapy However no prior studies have integrated this intervention into treatments for PTSD The proposed project will be guided by a user-centered design framework for treatment development and be conducted in three phases In the first phase the investigators will develop a modified CPT treatment manual that systematically integrates Memory Support with clinician n3 and Veteran n3 feedback to provide guidance on process and techniques In the next phase the investigators will conduct iterative refinement of the modified treatment through a case series in older Veterans n3 with an experienced CPT therapist Finally the investigators will conduct a small feasibility randomized controlled trial n20 in which the investigators will examine accrual retention completion acceptability and variability in symptom and functional outcomes as well as all procedures for a larger trial The proposed project offers substantial conceptual innovations by bridging foundational work from rehabilitation neuropsychology and psychotherapy mechanisms research and will provide valuable pilot data to inform a novel intervention for older Veterans with PTSD that can be tested in future large-scale studies Such approaches may be especially relevant for Veterans with neurocognitive deficits eg memory potentially suggesting a target for a personalized approach to mental health care
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1I21RX004627 | NIH | None | httpsreporternihgovquickSearch1I21RX004627 |