Ignite Creation Date:
2024-05-06 @ 7:25 PM
Last Modification Date:
2024-10-26 @ 3:06 PM
Study NCT ID:
NCT06002425
Status:
RECRUITING
Last Update Posted:
2023-09-08
First Post:
2023-08-13
Brief Title:
Treatment Recommendations for Gastrointestinal Cancers Via Large Language Models
Sponsor:
Chinese Academy of Sciences
Organization:
Chinese Academy of Sciences
Study Overview
Official Title:
Application of Large Language Models in the Recommendation of Treatment Plans for Gastrointestinal Cancers
Status:
RECRUITING
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will evaluate the utility of ChatGPT in recommending treatment plans for patients with gastrointestinal cancers using both retrospective and prospective data
Detailed Description:
The medical records of over 1200 patients with gastrointestinal cancers will be collected retrospectively from participating hospitals This data will be split into an exploratory dataset n200 and a validation dataset n1000 Within the exploratory dataset various prompt methods will be used to determine the treatment plans suggested by ChatGPT Additionally several clinicians of varied seniority levels will provide their treatment recommendations For the validation dataset ChatGPTs suggestions for treatment plans will undergo both qualitative and quantitative assessments by a multidisciplinary consultation MDT team The recommendations from ChatGPT will then be compared with those from the clinicians
Furthermore this study will incorporate a prospective dataset comprising 400 participants with gastrointestinal cancers The participants will be randomly allocated to either a control group n200 or a ChatGPT-Assisted group n200 In the control group treatment plan recommendations will solely be provided by the clinicians and will guide subsequent treatments In the ChatGPT-Assisted group initial treatment plan recommendations will be independently proposed by both ChatGPT and the clinicians Based on ChatGPTs suggestions clinicians might selectively adjust their initial plans Participants will then receive treatments as per these refined plans Within the ChatGPT-Assisted group the treatment plans of the initial 100 participants will be evaluated to determine the percentage of patients whose treatment plans are influenced by ChatGPT Subsequently the proportion of participants in the entire ChatGPT-Assisted group with treatment plans modified by ChatGPT will be calculated The study will further monitor the 3-year progression-free survival PFS and the 5-year overall survival OS rates contrasting the outcomes between the control and ChatGPT-assisted groups
Furthermore this study will incorporate a prospective dataset comprising 400 participants with gastrointestinal cancers The participants will be randomly allocated to either a control group n200 or a ChatGPT-Assisted group n200 In the control group treatment plan recommendations will solely be provided by the clinicians and will guide subsequent treatments In the ChatGPT-Assisted group initial treatment plan recommendations will be independently proposed by both ChatGPT and the clinicians Based on ChatGPTs suggestions clinicians might selectively adjust their initial plans Participants will then receive treatments as per these refined plans Within the ChatGPT-Assisted group the treatment plans of the initial 100 participants will be evaluated to determine the percentage of patients whose treatment plans are influenced by ChatGPT Subsequently the proportion of participants in the entire ChatGPT-Assisted group with treatment plans modified by ChatGPT will be calculated The study will further monitor the 3-year progression-free survival PFS and the 5-year overall survival OS rates contrasting the outcomes between the control and ChatGPT-assisted groups
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None