Ignite Creation Date:
2024-05-06 @ 7:24 PM
Last Modification Date:
2024-10-26 @ 3:06 PM
Study NCT ID:
NCT05997732
Status:
SUSPENDED
Last Update Posted:
2023-11-02
First Post:
2023-08-02
Brief Title:
Sympathetic Neurovascular Transduction Role of Adrenergic Receptors and Sex Differences
Sponsor:
University of Alberta
Organization:
University of Alberta
Study Overview
Official Title:
Sympathetic Neurovascular Transduction Role of Adrenergic Receptors and Sex Differences
Status:
SUSPENDED
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
No recruitment has occurred will start in early 2025
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
STARS
Brief Summary:
The main purpose of this interventional study is to examine differences in resting blood pressure control between healthy males and females The main questions it aims to answer are
1 Are there sex differences in the communication between the sympathetic nervous system also known as the fight or flight response and peripheral blood vessels which influence systemic blood pressure
2 What is the role of specific vascular receptors that respond to sympathetic signals and is it different between males and females
Participants will complete one study visit of approximately 3 hours where they will
Have a blood sample taken to measure circulating sex hormone and sympathetic transmitters
Receive very small doses of medications commonly used to adjust blood pressure through an artery in their arm The effects of these medications will be short-acting and localized to the forearm
Have their sympathetic nervous activity directly measured through two very small needles similar to acupuncture needles in the side of their leg
Have their blood pressure and heart rate recorded and forearm blood flow measured using ultrasound
1 Are there sex differences in the communication between the sympathetic nervous system also known as the fight or flight response and peripheral blood vessels which influence systemic blood pressure
2 What is the role of specific vascular receptors that respond to sympathetic signals and is it different between males and females
Participants will complete one study visit of approximately 3 hours where they will
Have a blood sample taken to measure circulating sex hormone and sympathetic transmitters
Receive very small doses of medications commonly used to adjust blood pressure through an artery in their arm The effects of these medications will be short-acting and localized to the forearm
Have their sympathetic nervous activity directly measured through two very small needles similar to acupuncture needles in the side of their leg
Have their blood pressure and heart rate recorded and forearm blood flow measured using ultrasound
Detailed Description:
Blood pressure is in part regulated by activity of your sympathetic nervous system also known as your fight or flight response Sympathetic nerve activity affects the size of your blood vessels which in turn will affect your blood pressure This communication between sympathetic impulses and the resulting change in vascular resistance is termed sympathetic neurovascular transduction In other words transduction represents the reactivity of the blood vessels in response to individual sympathetic bursts of activity
Males and females regulate their blood pressure in different ways for example females tend to have lower blood pressure and sympathetic nerve activity than males Females also appear to have less constriction of their blood vessels in response to stress This may be due to differences in the receptors which are activated by the sympathetic nervous system These receptors are called α and β-adrenergic receptors and are located on vascular smooth muscle cells They respond to sympathetic neurotransmitters such as norepinephrine in opposite directions α-adrenoreceptors cause vasoconstriction and an increase in vascular resistance and β-adrenoreceptors cause vasodilation and a decrease in vascular resistance in part through the endothelium-dependent nitric oxide pathway
Current evidence suggests that β-adrenergic receptors are more sensitive in females and contribute to paradoxical vasodilation when α-adrenergic receptors are stimulated by norepinephrine from sympathetic bursts It has also been suggested that estrogen interacts with adrenergic receptors contributing to this sex difference This study will contribute to the understanding of sex differences in cardiovascular physiology and may have implications for clinical cardiovascular conditions
Males and females regulate their blood pressure in different ways for example females tend to have lower blood pressure and sympathetic nerve activity than males Females also appear to have less constriction of their blood vessels in response to stress This may be due to differences in the receptors which are activated by the sympathetic nervous system These receptors are called α and β-adrenergic receptors and are located on vascular smooth muscle cells They respond to sympathetic neurotransmitters such as norepinephrine in opposite directions α-adrenoreceptors cause vasoconstriction and an increase in vascular resistance and β-adrenoreceptors cause vasodilation and a decrease in vascular resistance in part through the endothelium-dependent nitric oxide pathway
Current evidence suggests that β-adrenergic receptors are more sensitive in females and contribute to paradoxical vasodilation when α-adrenergic receptors are stimulated by norepinephrine from sympathetic bursts It has also been suggested that estrogen interacts with adrenergic receptors contributing to this sex difference This study will contribute to the understanding of sex differences in cardiovascular physiology and may have implications for clinical cardiovascular conditions
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None