Ignite Creation Date:
2024-05-06 @ 7:23 PM
Last Modification Date:
2024-10-26 @ 3:06 PM
Study NCT ID:
NCT05994677
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-08-16
First Post:
2023-08-09
Brief Title:
Psoriasis and Non Alcoholic Steatohepatitis Is There a Shared Inflammatory Network
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Psoriasis and Non Alcoholic Steatohepatitis Is There a Shared Inflammatory Network
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PANASH
Brief Summary:
The study is to assess frequency of NASH in Psoriatic patient and to measure the level of proinflammatory cytokines including TNFα interleukin IL-6 and IL-17 and anti-inflammatory cytokines including IL10 IL35 by ELISA
Detailed Description:
Psoriasis is a chronic proliferative and inflammatory condition of the skin It is characterized by erythematous plaques covered with silvery scales particularly over the extensor surfaces scalp and lumbosacral region
The disorder can also affect the joints and eyes Psoriasis has no cure and the disease waxes and wanes with flareups There are several subtypes of psoriasis but the plaque type is the most common and presents on the trunk extremities and scalp
Psoriasis has a prevalence ranging from 02 to 48
In parallel nonalcoholic fatty liver disease NAFLD is the most frequent liver disease worldwide affecting an estimated 30 of the adult population in developed countries
NAFLD and the metabolic syndrome are mutually and bi-directionally associated as these two pathologic condition share insulin resistance as a common pathophysiological mechanism
NAFLD encompasses a spectrum of pathologic conditions ranging from simple steatosis to nonalcoholic steatohepatitisNASH featuring steatosis associated with inflammatory changes hepatocellular ballooning and pericellular fibrosis to advanced fibrosis and cirrhosis NAFLD is projected to become the most common indication for liver transplantation in the United States by 2030
Over the last few years multiple studies have demonstrated that psoriasis is associated with NAFLD The majority reported a prevalence of around 50 range 144 to 655 for NAFLD in psoriatic patients
The contribution of IL-17 to the pathogenesis of both psoriasis and NAFLD is intriguing Th17 cells can be detected in fat tissue and IL-17 itself regulates glucose metabolism and adipogenesis Likewise IL-17A-secreting Th17 cells may promote the progression from simple steatosis to steatohepatitis 10 Therefore both psoriasis and NAFLD pathogenesis seem to be linked to the joint proinflammatory Th17 axis and other cytokines such as TNFα and IL-6
The disorder can also affect the joints and eyes Psoriasis has no cure and the disease waxes and wanes with flareups There are several subtypes of psoriasis but the plaque type is the most common and presents on the trunk extremities and scalp
Psoriasis has a prevalence ranging from 02 to 48
In parallel nonalcoholic fatty liver disease NAFLD is the most frequent liver disease worldwide affecting an estimated 30 of the adult population in developed countries
NAFLD and the metabolic syndrome are mutually and bi-directionally associated as these two pathologic condition share insulin resistance as a common pathophysiological mechanism
NAFLD encompasses a spectrum of pathologic conditions ranging from simple steatosis to nonalcoholic steatohepatitisNASH featuring steatosis associated with inflammatory changes hepatocellular ballooning and pericellular fibrosis to advanced fibrosis and cirrhosis NAFLD is projected to become the most common indication for liver transplantation in the United States by 2030
Over the last few years multiple studies have demonstrated that psoriasis is associated with NAFLD The majority reported a prevalence of around 50 range 144 to 655 for NAFLD in psoriatic patients
The contribution of IL-17 to the pathogenesis of both psoriasis and NAFLD is intriguing Th17 cells can be detected in fat tissue and IL-17 itself regulates glucose metabolism and adipogenesis Likewise IL-17A-secreting Th17 cells may promote the progression from simple steatosis to steatohepatitis 10 Therefore both psoriasis and NAFLD pathogenesis seem to be linked to the joint proinflammatory Th17 axis and other cytokines such as TNFα and IL-6
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None