Ignite Creation Date:
2024-05-06 @ 7:22 PM
Last Modification Date:
2024-10-26 @ 3:05 PM
Study NCT ID:
NCT05990309
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-08-14
First Post:
2023-08-06
Brief Title:
ASSESSMENT OF TRISTETRAPROLIN EXPRESSION IN LESIONAL SKIN OF PATIENTS WITH NON SEGMENTAL VITILIGO
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
ASSESSMENT OF TRISTETRAPROLIN EXPRESSION IN LESIONAL SKIN OF PATIENTS WITH NON SEGMENTAL VITILIGO
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Vitiligo is characterized by the selective loss of melanocytes which in turn leads to totally amelanotic non-scaly chalky-white macule with distinct margins Vitiligo is the most common depigmenting skin disorder with an estimated prevalence of 05-2 of the population in both adults and children worldwide Tumor necrosis factor TNF-α a pro-inflammatory cytokine is necessary for Th1 mediated response and immune homeostasis and the up-regulation of TNF-α can result in chronic inflammatory and autoimmune diseases previous studies revealed a rise in transcript and protein levels of TNF-α in vitiligo patients The prime location of melanocytes keratinocytes and fibroblasts is the epidermal microenvironment and these cells are capable of TNF-α expression and secretion TNF-α acts as an autocrine as well as a paracrine manner to suppress the melanocyte growth and proliferation Tristetraprolin TTP zinc finger protein 36 ZFP36 is Ribonucleic acid RNA binding protein that preferentially binds to Adenylate-uridylate-rich AU-rich regions in the 3 untranslated regions 3UTR of target genes Additionally Tristetraprolin functions by destabilizing mRNAs encoding for oncogenes cytokines as TNFα and chemokines involved in the inflammatory processes by favoring their degradation andor preventing their efficient translation The expression of proinflammatory mediator genes is tightly controlled by post-transcriptional regulation which is mediated by a set of immune-related RNA binding proteins such as tristetraprolin Roquin and Regnase
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None