Ignite Creation Date:
2024-05-06 @ 7:22 PM
Last Modification Date:
2024-10-26 @ 3:05 PM
Study NCT ID:
NCT05985369
Status:
COMPLETED
Last Update Posted:
2024-04-24
First Post:
2023-08-02
Brief Title:
Vegan and Omnivorous Diets and Skeletal Muscle Turnover in Healthy Older Adults
Sponsor:
University of Exeter
Organization:
University of Exeter
Study Overview
Official Title:
The Effects of a High-quality Vegan Diet on Skeletal Muscle Maintenance and Adaptation in Comparison to a Protein-matched Omnivorous Diet in Healthy Older Adults
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MVP
Brief Summary:
Dietary protein intake and physical activity are key to minimise the age-related loss of skeletal muscle mass While animal-derived protein sources are considered high-quality anabolic foods it remains unclear whether non-animal-derived vegan protein sources support skeletal muscle maintenance and healthy ageing The aim of the present study is to assess the effect of a vegan diet on daily muscle protein synthesis rates compared to a protein-matched omnivorous diet where the majority of protein is derived from high-quality animal-based protein sources
Detailed Description:
Background The age-related loss of muscle mass and strength is partly explained by a blunted responsiveness of skeletal muscle to the anabolic properties of dietary protein and muscle contraction Therefore sufficient dietary protein intake and physical activity are required to minimise age-related muscle atrophy It remains unknown whether this can be achieved utilising non-animal-derived vegan protein sources
Objective To assess daily muscle protein synthesis rates when adopting a vegan or protein-matched omnivorous control diet
Methods Healthy older adults aged 60-80 years will be randomly allocated to a completely controlled 1-week vegan providing 08 gkg BWday protein or protein-matched omnivorous diet During this week participants will perform a set of unilateral leg resistance exercise on day 1 3 and 5 Deuterium oxide in combination with saliva and muscle sample from the m vastus lateralis collection will be used to measure daily muscle protein synthesis rates in resting and exercised tissue
Value This will be the first study assessing daily muscle protein turnover in healthy older adults adopting a 1-week vegan diet This will contribute to the understanding and viability of vegan protein to support active and healthy ageing
Objective To assess daily muscle protein synthesis rates when adopting a vegan or protein-matched omnivorous control diet
Methods Healthy older adults aged 60-80 years will be randomly allocated to a completely controlled 1-week vegan providing 08 gkg BWday protein or protein-matched omnivorous diet During this week participants will perform a set of unilateral leg resistance exercise on day 1 3 and 5 Deuterium oxide in combination with saliva and muscle sample from the m vastus lateralis collection will be used to measure daily muscle protein synthesis rates in resting and exercised tissue
Value This will be the first study assessing daily muscle protein turnover in healthy older adults adopting a 1-week vegan diet This will contribute to the understanding and viability of vegan protein to support active and healthy ageing
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None