Ignite Creation Date:
2024-05-06 @ 7:21 PM
Last Modification Date:
2024-10-26 @ 3:05 PM
Study NCT ID:
NCT05985577
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2023-08-14
First Post:
2023-07-17
Brief Title:
Mechanism of Gastric Signet Ring Cell Carcinoma Based on Microproteomics
Sponsor:
Zhejiang Cancer Hospital
Organization:
Zhejiang Cancer Hospital
Study Overview
Official Title:
Mechanism of Gastric Signet Ring Cell Carcinoma Based on Microproteomics
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2023-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Gastric signet ring cell carcinoma GSRCC possesses unique epidemiology and pathogenesis in the field of cancer but its incidence is low Unfortunately there is currently a lack of systematic research focusing on the prognostic proteomic features of GSRCC Given this knowledge gap this study aims to comprehensively characterize the proteomic landscape of GSRCC using a reliable and reproducible DIA-PCT method This study objectives include characterizing the heterogeneity of GSRCC performing molecular typing identifying potential biomarkers and therapeutic targets and providing a resource for stratified analysis of GSRCC To achieve these goals the investigators selected a cohort of 112 GSRCC patients from a pool of over 10000 gastric cancer patients and conducted a proteomic analysis using the DIA-PCT method This meticulous approach revealed four novel proteomic subtypes of GSRCC each exhibiting unique molecular characteristics Additionally the investigators discovered that PRDX2 and DDX27 can serve as predictive biomarkers for GSRCC which were further validated in an independent cohort of 75 GSRCC patients Furthermore the investigators paid particular attention to the MLT-GSRCC subgroup and identified three distinct proteomic clusters among MLT-GSRCC patients Subtype 2 within this subgroup demonstrated the poorest prognosis Through a rigorous screening process the investigators determined potential targets for the treatment of GSRCC In conclusion these findings contribute to the investigators understanding of the heterogeneity of GSRCC and provide valuable resources for future clinical stratification and targeted treatment strategies
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None