Viewing Study NCT05977439



Ignite Creation Date: 2024-05-06 @ 7:20 PM
Last Modification Date: 2024-10-26 @ 3:05 PM
Study NCT ID: NCT05977439
Status: RECRUITING
Last Update Posted: 2024-04-26
First Post: 2023-06-29

Brief Title: RECOVERS - Realigning Emotion and COgnition Via PrEcision Regulation NetworkS
Sponsor: Medical University of South Carolina
Organization: Medical University of South Carolina

Study Overview

Official Title: RECOVERS - Realigning Emotion and COgnition Via PrEcision Regulation NetworkS - Phase I Study Multimodal Computational Modeling of Cognitive Flexibility and Emotion Regulation Networks
Status: RECRUITING
Status Verified Date: 2024-07
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: In this research study the investigators are examining how brain activity electrical and blood flow changes during tests of emotional processing attention and memory in the magnetic resonance imaging MRI scanner and outside the MRI using functional near-infrared spectroscopy fNIRS Investigators are also using non-invasive brain stimulation to probe different parts of the brain and measuring brain activity electrical and blood flow

Study 1

This study includes healthy participants and researchers hope this will help us develop improved brain-based treatments for emotional difficulties like depression

Study 2

This study includes participants with depression and researchers hope this will help us develop improved brain-based treatments for emotional difficulties like depression
Detailed Description: Investigators hypothesize that targeted neuroplastic changes induced by individually-tailored rTMS will substantially reduce clinical symptoms underlying depression anxiety and suicidality and in general revolutionize non-invasive treatments of mental health disorders Investigators hypothesize that functional coupling in cognitive flexibility CF and emotion regulation ER networks is indexed by the phase of the brains alpha oscillations Using a novel integrated instrument that enables simultaneous functional magnetic resonance imaging fMRI electroencephalography EEG and transcranial magnetic stimulation TMS investigators propose to identify individualized stimulation parameters that reflect the strongest coupling of the CFER networks Investigators will also use an instrument that enables simultaneous functional near-infrared spectroscopy fNIRS EEG and TMS in attempt to identify the same parameters outside the scanner The neuromechanistic model further posits that by applying repetitive TMS rTMS with these individualized parameters one can induce entrainment in brain networks that drive neuroplastic changes in CF and ER

Study 1

This study is a proof-of-principle study in healthy control participants

Study 2

This study is a proof-of-principle study in participants with depression

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: False
Is a FDA Regulated Device?: True
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: False
Is an FDA AA801 Violation?: None