Ignite Creation Date:
2025-12-24 @ 12:55 PM
Ignite Modification Date:
2025-12-28 @ 9:36 AM
Study NCT ID:
NCT07177261
Status:
NOT_YET_RECRUITING
Last Update Posted:
2025-11-14
First Post:
2025-09-02
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Inter-Brain Synchrony in Schizophrenia
Sponsor:
University of California, Los Angeles
Organization:
Study Overview
Official Title:
Inter-Brain Synchrony as a Neural Mechanism of Social Connection in Schizophrenia
Status:
NOT_YET_RECRUITING
Status Verified Date:
2025-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this clinical trial is to investigate for the first time in people with schizophrenia a neural mechanism that is thought to facilitate the formation of social connections - inter-brain synchrony - in order to improve scientific understanding of the neural mechanisms of social dysfunction in the disorder, and to provide a basis for the development of new and better treatments to improve social functioning and connectedness in the illness. The main questions it aims to answer are:
1. Investigate inter-brain synchrony as a neural mechanism of social connection in schizophrenia
2. Manipulate social closeness and test for effects on inter-brain synchrony across groups
The investigators will compare results from people with schizophrenia to a healthy comparison group (controls) who do not have psychotic disorders to see if inter-brain synchrony is greater in controls. Investigators will also compare measures of inter-brain synchrony before and after the social closeness manipulation to see if inter-brain synchrony changes with increasing closeness.
Participants will:
* Have a clinicial diagnostic interview and be assessed for clinical symptoms
* Have an EEG recorded while interacting with another person. Participants will first work with the other person to draw a figure, and then tap fingers together. Participants will then either undergo the experimental manipulation to increase social closeness (called, "fast friends") or undergo the control condition that does not increase social closeness (called "small talk"). Participants will then repeat the drawing and finger tapping assessment.
* After completing the experimental or control condition, participants will then repeat the procedure with the other condition that was not yet done.
* Be interviewed on the number and quality of social interactions.
1. Investigate inter-brain synchrony as a neural mechanism of social connection in schizophrenia
2. Manipulate social closeness and test for effects on inter-brain synchrony across groups
The investigators will compare results from people with schizophrenia to a healthy comparison group (controls) who do not have psychotic disorders to see if inter-brain synchrony is greater in controls. Investigators will also compare measures of inter-brain synchrony before and after the social closeness manipulation to see if inter-brain synchrony changes with increasing closeness.
Participants will:
* Have a clinicial diagnostic interview and be assessed for clinical symptoms
* Have an EEG recorded while interacting with another person. Participants will first work with the other person to draw a figure, and then tap fingers together. Participants will then either undergo the experimental manipulation to increase social closeness (called, "fast friends") or undergo the control condition that does not increase social closeness (called "small talk"). Participants will then repeat the drawing and finger tapping assessment.
* After completing the experimental or control condition, participants will then repeat the procedure with the other condition that was not yet done.
* Be interviewed on the number and quality of social interactions.
Detailed Description:
None
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
Secondary ID Infos
| Secondary ID | Type | Domain | Link | View |
|---|---|---|---|---|
| 1R21MH139044-01A1 | NIH | None | https://reporter.nih.gov/quic… | View |