Ignite Creation Date:
2024-05-06 @ 7:19 PM
Last Modification Date:
2024-10-26 @ 3:05 PM
Study NCT ID:
NCT05977153
Status:
RECRUITING
Last Update Posted:
2023-08-04
First Post:
2023-07-28
Brief Title:
CT for Personalized Mechanical Ventilation
Sponsor:
Columbia University
Organization:
Columbia University
Study Overview
Official Title:
CT-Guided Personalized Mechanical Ventilation to Minimize Ventilator-Induced Lung Injury Study
Status:
RECRUITING
Status Verified Date:
2023-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this study is to compare two different ways of helping patients with a condition called sepsis who need help breathing using a machine called a ventilator The investigators want to study which way of setting the ventilator is better for the lungs
Here are the main questions the investigators want to answer
1 How does the amount of air in the lungs and the way it moves differ between the two ways
2 How does the way air spreads out in different parts of the lungs differ between the two ways In this study the investigators will take special pictures of the lungs using a machine called a CT scan The pictures will show us how much the lungs stretch and how much air is in different parts of the lungs The investigators will compare two different ways of using the ventilator one personalized for each patient based on their breathing and another way that is commonly used
By comparing these two ways the investigators hope to learn which one is better for helping patients with sepsis who need the ventilator This information can help doctors make better decisions about how to care for these patients and improve their breathing
Here are the main questions the investigators want to answer
1 How does the amount of air in the lungs and the way it moves differ between the two ways
2 How does the way air spreads out in different parts of the lungs differ between the two ways In this study the investigators will take special pictures of the lungs using a machine called a CT scan The pictures will show us how much the lungs stretch and how much air is in different parts of the lungs The investigators will compare two different ways of using the ventilator one personalized for each patient based on their breathing and another way that is commonly used
By comparing these two ways the investigators hope to learn which one is better for helping patients with sepsis who need the ventilator This information can help doctors make better decisions about how to care for these patients and improve their breathing
Detailed Description:
Mechanical ventilation is a key life support method applied to millions of surgical and critically ill patients Ventilator-induced lung injury VILI is a major factor for morbidity and mortality in patients with the acute respiratory distress syndrome ARDS the most severe form of respiratory dysfunction Furthermore mechanical ventilation settings also contribute to the risk for postoperative pulmonary complications PPCs in surgical patients and lung injury in critically ill patients with normal lungs at onset of ventilation In summary mitigation of VILI is critical to reduce perioperative and critical care morbidity and mortality with major impact on outcomes and health care costs
In this project we propose to apply novel CT methods to assess spatial distributions of strain and aeration and establish measures of global lung mechanics best indicative of the PEEP leading to least injurious distributions and thus least VILI
In this project we propose to apply novel CT methods to assess spatial distributions of strain and aeration and establish measures of global lung mechanics best indicative of the PEEP leading to least injurious distributions and thus least VILI
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 5R01HL121228-09 | NIH | None | httpsreporternihgovquickSearch5R01HL121228-09 |