Ignite Creation Date:
2024-05-06 @ 7:18 PM
Last Modification Date:
2024-10-26 @ 3:04 PM
Study NCT ID:
NCT05962099
Status:
RECRUITING
Last Update Posted:
2023-07-27
First Post:
2023-05-22
Brief Title:
Defining Circadian Metabolism in Non-alcoholic Fatty Liver Disease
Sponsor:
University of Oxford
Organization:
University of Oxford
Study Overview
Official Title:
Defining Circadian Metabolism in Non-alcoholic Fatty Liver Disease
Status:
RECRUITING
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DECIMAL
Brief Summary:
The investigators will conduct an open label experimental medicine study exploring the diurnal patterns of hepatic lipid metabolism in NAFLD and non-NAFLD participants determined by Transient elastography TE with controlled attenuation parameter CAP We will also determine whether the diurnal patterns of lipid metabolism in NAFLD participants can be modified using lifestyle and weight loss intervention Fourteen participants without NAFLD will have morning and evening metabolic investigations visit 1M 1E to assess for changes in lipid flux pathways across the course of the day After morning and evening investigations their involvement in the clinical study will then end Seventeen NAFLD participants will also have identical baseline morning and evening investigation after which they will be enrolled into a 12-week lifestyle and weight loss programme After 12-weeks all 17 participants with NAFLD will have a follow up CAP and morning and evening metabolic investigations visit 2M 2E
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None