Ignite Creation Date:
2024-05-06 @ 7:16 PM
Last Modification Date:
2024-10-26 @ 3:03 PM
Study NCT ID:
NCT05951426
Status:
COMPLETED
Last Update Posted:
2023-07-19
First Post:
2023-06-22
Brief Title:
Expression Analysis of the COPB 2 and Bcl-2 in Early Stages of Endometrial Carcinoma
Sponsor:
Clinical Center Kragujevac
Organization:
Clinical Center Kragujevac
Study Overview
Official Title:
A Study Without a Protocol Number Documentation Filed in the Registry Under Number 01191438 Date 08042019
Status:
COMPLETED
Status Verified Date:
2023-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
COPB2 is a subunit of the intracellular transport system between cell organelles that participates in the regulation of cell division and differentiation Bcl-2 is a protein that participates in regulating the process of apoptosis Through the researchinvestigators tried to examine and establish the correlation of the expression of these two genes in endometrial cancer at an early stage
Detailed Description:
The research was conducted as a prospective controlled clinical experimental study in the period from 2019-2022 in patients who were treated at the Gynecology and Obstetrics Clinic in Clinical Center Kragujevac Sections of tissue deriving from the exploratory curettage and operative procedure were taken after obtaining informed consent of participants with the declaration of Helsinki and recommendations of the World Health Organization for experiments on human material and after getting approval of the Ethics Committee
Participants are divided into two groups Investigators stored the sample endometrial tissue in liquid nitrogen under adequate conditions at the Kragujevac Clinical Center department for Gynecology and Obstetrics and examined the expression of the COPB2 and Bcl-2 gene in endometrial tissue cells of these two groups of patients In order to examine the relative expression of the gene for the COPB2 subunit and Bcl-2 investigators sampled endometrial tissue from patients with endometrial cancer - experimental group and from patients without cancer - control group All participants of the experimental group had initial stages of cancer without the existence of metastases at the time of taking the sample for the study Gene expression was performed using the Polymerase Chain Reaction method at the Faculty of Science and Mathematics in Kragujevac
Participants are divided into two groups Investigators stored the sample endometrial tissue in liquid nitrogen under adequate conditions at the Kragujevac Clinical Center department for Gynecology and Obstetrics and examined the expression of the COPB2 and Bcl-2 gene in endometrial tissue cells of these two groups of patients In order to examine the relative expression of the gene for the COPB2 subunit and Bcl-2 investigators sampled endometrial tissue from patients with endometrial cancer - experimental group and from patients without cancer - control group All participants of the experimental group had initial stages of cancer without the existence of metastases at the time of taking the sample for the study Gene expression was performed using the Polymerase Chain Reaction method at the Faculty of Science and Mathematics in Kragujevac
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None