Ignite Creation Date:
2024-05-06 @ 7:14 PM
Last Modification Date:
2024-10-26 @ 3:03 PM
Study NCT ID:
NCT05946278
Status:
RECRUITING
Last Update Posted:
2024-04-03
First Post:
2023-07-07
Brief Title:
Genetic Regulators of Bone Health That Are Unique to Vertebral Bone
Sponsor:
University of Colorado Denver
Organization:
University of Colorado Denver
Study Overview
Official Title:
Identification and Characterization of Genetic Regulators of Bone Health That Are Unique to Vertebral Bone
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Osteoporosis is an age related disease in which a persons bone slowly becomes weaker with time The bones may become so weak that they break easily such as a fall from standing height The most commonly broke bones in osteoporosis are those of the hip the spine or the wrist Osteoporosis runs in families meaning that genetic differences explain why some people break bones in old age and other do not Genetic studies have been done that show the the genes associated with spine vertebral fractures broken bones and hip fractures are different suggesting that osteoporosis of the spine is not the exact same disease as osteoporosis of the hip Genetic studies tell us what part of the genome ie genes are associated with a disease but do not tell us how these genes act biologically to cause that disease In this study we seek to determine how the genes uniquely associated with spine osteoporosis behave in normal and aged bone to determine how they interact with each other as a team to impact spine bone In this study we will measure gene activity so called gene expression in bone samples taken from people undergoing major spine deformity surgery We will using genetic data from these patients to determine how gene activity is controlled in bone and how that relates to measures of bone health such as bone mineral density data The results of this study will provide critical data regarding how osteoporosis of the spine happens and these data will be used to find better and safer treatments to prevent bone fractures of the spine that happen with age
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None