Ignite Creation Date:
2024-05-06 @ 7:13 PM
Last Modification Date:
2024-10-26 @ 3:02 PM
Study NCT ID:
NCT05933109
Status:
RECRUITING
Last Update Posted:
2023-07-11
First Post:
2023-06-20
Brief Title:
Mental Imagery and Targeted Memory Reactivation in PTSD
Sponsor:
University Hospital Geneva
Organization:
University Hospital Geneva
Study Overview
Official Title:
Augmentation of Imagery Rehearsal Therapy With Targeted Memory Reactivation for Post-Traumatic Stress Disorder PTSD
Status:
RECRUITING
Status Verified Date:
2023-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
With this protocol investigators examine whether targeted memory reactivation TMR a technique used to strengthen memories can accelerate remission of traumatic nightmares and post-traumatic stress disorder PTSD symptomatology This protocol uses TMR during REM sleep to strengthen positive memories generated by Imagery Rehearsal Therapy IRT a recommended treatment of nightmares Patients with PTSD are asked to perform 3 weekly IRT sessions and while they generate a positive outcome of their recurrent nightmare half of the patients are exposed to a sound S1 TMR group while the other half is not exposed to this sound control group All patients will perform IRT every evening at home and will be exposed to the sound S1 during REM sleep with a wireless headband which automatically detects sleep stages Clinical evaluation of the severity of PTSD and nightmares before and after 1-month follow-up and 3-months follow-up this intervention takes place using the validated Clinically Administered PTSD Scale for DSM-5 CAPS-5 primary outcome measure The investigators hypothesize that patients treated with IRT and who are exposed during REM sleep to a sound that had previously been associated with the new positive dream scenario of IRT TMR group will have more reduced frequency of PTSD severity and nightmares compared to participants with stimulation of the same but non-associated sound during REM sleep control group
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None